Evidence map›Paper›PMID 33688222›Full record

ArticleInfection and drug resistance2021

Antibiotic Susceptibility Patterns of Bacterial Isolates from Routine Clinical Specimens from Referral Hospitals in Tanzania: A Prospective Hospital-Based Observational Study.

Nicholaus P Mnyambwa, Coline Mahende, Amani Wilfred, Erica Sandi, Nicodem Mgina, Clara Lubinza, Amos Kahwa, Pammla Petrucka, Sayoki Mfinanga, Esther Ngadaya and 1 more

Abstract read
In one paragraph

Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicholaus P MnyambwaNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Coline MahendeNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Amani WilfredNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Erica SandiNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Nicodem MginaCentral Tuberculosis Reference Laboratory (CTRL), Dar es Salaam, Tanzania.
Clara LubinzaNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Amos KahwaNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.
Pammla PetruckaSchool of Life Science and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.ORCID 0000-0003-3174-3328
Sayoki MfinangaNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.ORCID 0000-0001-9067-2684
Esther NgadayaNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.ORCID 0000-0003-4540-5637
Godfather KimaroNational Institute for Medical Research, Muhimbili Research Centre, Dar es Salaam, Tanzania.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionAntimicrobial resistance is one of the biggest threats of modern public health. Although sub-Saharan Africa is highly burdened with infectious diseases, current data on antimicrobial resistance are sparse.

methodsA prospective study was conducted between October 2018 and September 2019 to assess the antibiotic susceptibility patterns of clinical bacterial isolates obtained from four referral hospitals in Tanzania. We used standard media and Kirby-Bauer disc diffusion methods as per Clinical and Laboratory Standards Institute (CLSI) standards.

resultsWe processed a total of 2620 specimens of which 388 (14.8%) were culture-positive from patients with a median (IQR) age of 28 (12-44) years. Of the positive cultures, 52.3% (203) were from females. Most collected specimens were ear pus 28.6% (111), urine 24.0% (93), wound pus 20.6% (80), stool 14.9% (58), and blood 8.3% (32). Predominant isolates were

conclusionAntibiotic resistance to commonly prescribed antibiotics was alarmingly high. Our findings emphasize the need for comprehensive national control programs to combat antibiotic resistance.

Indexed as

AMRantibioticsantibiotic susceptibility testingantimicrobial resistancebacterial isolatesmethicillin-resistant Staphylococcus aureusMRSA

Identifiers

PMID33688222
PMCPMC7937390

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.