Evidence map›Paper›PMID 33688165›Full record

ArticleDrug design, development and therapy2021

Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats.

Wei Liang, Pengbing Ding, Guan Li, Enhang Lu, Zhenmin Zhao

Erratum issuedAbstract read
In one paragraph

Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  6. Research Progress in Medical Biomaterials for Bone Infections.Journal of functional biomaterials · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wei LiangDepartment of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Pengbing DingDepartment of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Guan LiDepartment of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.ORCID 0000-0002-2721-6667
Enhang LuDepartment of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Zhenmin ZhaoDepartment of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe potential of relapse of craniofacial disharmony after trans-sutural distraction osteogenesis is high due to the failure to produce a stable bone bridge in the suture gap. The aim of this study is to evaluate whether hydroxyapatite nanoparticles (nHAP) have the effect of promoting osteoblast differentiation of suture-derived stem cells (SuSCs) and bone formation in sagittal suture during expansion.

methodsSuSCs were isolated from sagittal sutures and exposed to various concentrations of nHAP (0, 25, 50, and 100 μg mL

resultsThe expression of osteoblast related genes and proteins induced by 25μg mL

conclusionThe 25μg mL

Indexed as

AnimalsCell DifferentiationCells, CulturedCranial SuturesDose-Response Relationship, DrugDurapatiteMaleMolecular StructureNanoparticlesOsteoblastsOsteogenesisRatsRats, Sprague-DawleyStructure-Activity RelationshipDurapatitebone formationhydroxyapatite nanoparticlesosteoblast differentiationsagittal suturesuture-derived stem cells

Identifiers

PMID33688165
PMCPMC7936535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.