Evidence map›Paper›PMID 33688025›Full record

ArticleCMAJ open

Concordance between high antibiotic prescribing and high opioid prescribing among primary care physicians: a cross-sectional study.

Bradley J Langford, Cynthia Chen, Nick Daneman, Kevin A Brown, Tara Gomes, Jennie Johnstone, Julie Wu, Valerie Leung, Gary Garber, Kevin L Schwartz

Abstract read
In one paragraph

Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Androgen deprivation therapy for prostate cancer: Prescribing behaviors and preferences among urologists.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bradley J LangfordPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont. bradley.langford@oahpp.ca.
Cynthia ChenPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Nick DanemanPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Kevin A BrownPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Tara GomesPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Jennie JohnstonePublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Julie WuPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Valerie LeungPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Gary GarberPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.
Kevin L SchwartzPublic Health Ontario (Langford, Chen, Daneman, Brown, Johnstone, Wu, Leung, Garber, Schwartz), Toronto, Ont.; Hotel Dieu Shaver Health and Rehabilitation Centre (Langford), St. Catharines, Ont.; ICES Central (Chen, Gomes, Schwartz); Sunnybrook Health Sciences Centre (Daneman); Dalla Lana School of Public Health (Brown, Schwartz), University of Toronto; Keenan Research Centre of the Li Ka Shing Knowledge Institute (Gomes), St. Michael's Hospital; Sinai Health System (Johnstone); Michael Garron Hospital (Leung), Toronto East Health Network, Toronto, Ont.; Ottawa Hospital Research Institute (Garber), Ottawa, Ont.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance and opioid misuse both present major public health challenges, and identifying high prescribers of both of these agents can help provide a common target for intervention. We sought to determine the association between being a high prescriber of antibiotics and being a high prescriber of opioids in the primary care setting.

methodsWe performed a cross-sectional study of the antibiotic- and opioid-prescribing habits of primary care physicians in Ontario, Canada between Mar. 1, 2017, and Feb. 28, 2018, using administrative databases. We defined high prescribers as the top quartile of antibiotic or opioid prescribers using 3 antibiotic-prescribing metrics (prescriptions per patient visit, proportion of prescriptions that were broad spectrum and proportion of prescriptions > 8 d) and 3 opioid-prescribing metrics (prescriptions per patients seen, proportion of prescriptions > 90 mg of morphine equivalents and proportion of prescriptions > 28 d). We tabulated agreement between prescribing metrics using the κ statistic.

resultsWe included 9994 physicians. We observed minimal overlap between high antibiotic initiation and high opioid initiation (618 physicians [6.2%]) (κ = 0.00, 95% confidence interval -0.02 to 0.02). There was slight agreement between the antibiotic-prescribing indices and between the opioid-prescribing indices (within-class, range of κ 0.05 to 0.18). There was slight disagreement to slight agreement across antibiotic- and opioid-prescribing metrics (between-class, range of κ -0.09 to 0.16).

interpretationAmong primary care physicians, there was a lack of association between high antibiotic prescribing and high opioid prescribing. Our findings suggest that separate tailored approaches to antibiotic and opioid stewardship strategies are needed.

Indexed as

AdultAnalgesics, OpioidAnti-Bacterial AgentsCross-Sectional StudiesFemaleHumansMaleMiddle AgedOntarioPhysicians, Primary CarePractice Patterns, Physicians'Analgesics, OpioidAnti-Bacterial Agents

Identifiers

PMID33688025
PMCPMC8034295

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.