Evidence map›Paper›PMID 33688012›Full record

ArticlemBio2021

Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator.

Shruti Nagaraja, Maggi W Cai, Jingjing Sun, Hugo Varet, Lotem Sarid, Meirav Trebicz-Geffen, Yana Shaulov, Mohit Mazumdar, Rachel Legendre, Jean-Yves Coppée and 8 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. EnterohemorrhagicmSystems · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. RNA modification is the mark and strategy for host-microbe interactions.Cellular and molecular life sciences : CMLS · 2025
    Review
  10. Queuosine tRNA Modification: Connecting the Microbiome to the Translatome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 6 countries.

Shruti NagarajaDepartment of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Maggi W CaiDepartment of Microbiology and Immunology, National University of Singapore, Singapore.
Jingjing SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Hugo VaretPlate-forme Technologique Biomics, Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Paris, France.ORCID 0000-0003-3980-4463
Lotem Sarid *Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Meirav Trebicz-Geffen *Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Yana Shaulov *Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Mohit MazumdarJawaharlal Nehru University School of Life Sciences, New Delhi, India.
Rachel LegendrePlate-forme Technologique Biomics, Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Paris, France.
Jean-Yves CoppéePlate-forme Technologique Biomics, Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Paris, France.
Thomas J BegleyDepartment of Biological Sciences, The RNA Institute at the University at Albany, State University of New York at Albany, Albany, New York, USA.
Peter C DedonSingapore-MIT Alliance for Research and Technology, Singapore.
Samudrala GourinathJawaharlal Nehru University School of Life Sciences, New Delhi, India.
Nancy GuillenCentre National de la Recherche Scientifique, CNRS-ERL9195, Paris, France.
Yumiko Saito-NakanoDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
Chikako ShimokawaDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
Hajime HisaedaDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.
Serge AnkriDepartment of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel sankri@tx.technion.ac.il.ORCID 0000-0002-8775-1557
Technion – Israel Institute of Technology · ILCentre National de la Recherche Scientifique · FRNational Institute of Infectious Diseases · JPJawaharlal Nehru University · INMassachusetts Institute of Technology · USNational University of Singapore · SGSingapore-MIT Alliance for Research and Technology · SGUniversity at Albany, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to synthesize queuine, the nucleobase precursor to queuosine, and must obtain it from diet or gut microbiota. Here, we describe the effects of queuine on the physiology of the eukaryotic parasite

Indexed as

AnimalsEntamoeba histolyticaFemaleGuanineHeLa CellsHumansMethylationMiceMice, Inbred BALB COxidative StressRNA, TransferGuaninequeuineRNA, TransferEntamoeba histolyticaoxidative stresstRNA modificationvirulence

Identifiers

PMID33688012
PMCPMC8092309
OpenAlexW3134611871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.