Evidence map›Paper›PMID 33688001›Full record

ArticlemBio2021

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony.

Abigail J Perrin, Claudine Bisson, Peter A Faull, Matthew J Renshaw, Rebecca A Lees, Roland A Fleck, Helen R Saibil, Ambrosius P Snijders, David A Baker, Michael J Blackman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Malaria vaccines: a new era of prevention and control.Nature reviews. Microbiology · 2024
    Review
  12. The molecular mechanisms driving Plasmodium cell division.Biochemical Society transactions · 2024
    Review
  13. Review
  14. Article
  15. Microbiology spectrum · 2023
    Article
  16. Article
  17. Review
  18. Current approaches to malaria vaccines.Current opinion in microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Abigail J PerrinMalaria Biochemistry Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-6682-4297
Claudine BissonDepartment of Biological Sciences, Institute of Structural & Molecular Biology, Birkbeck College, University of London, London, United Kingdom.
Peter A FaullMass Spectrometry Proteomics Platform, The Francis Crick Institute, London, United Kingdom.
Matthew J RenshawAdvanced Light Microscopy, The Francis Crick Institute, London, United Kingdom.
Rebecca A LeesDepartment of Biological Sciences, Institute of Structural & Molecular Biology, Birkbeck College, University of London, London, United Kingdom.
Roland A FleckCentre for Ultrastructural Imaging, Guy's Campus, King's College London, London, United Kingdom.
Helen R SaibilDepartment of Biological Sciences, Institute of Structural & Molecular Biology, Birkbeck College, University of London, London, United Kingdom.
Ambrosius P SnijdersMass Spectrometry Proteomics Platform, The Francis Crick Institute, London, United Kingdom.
David A BakerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-5490-8933
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute, London, United Kingdom mike.blackman@crick.ac.uk.ORCID 0000-0002-7442-3810
The Francis Crick Institute · GBBirkbeck, University of London · GBKing's College London · GBLondon School of Hygiene & Tropical Medicine · GB

Funding

Cancer Research UK FC001043Medical Research Council FC001043Medical Research Council MR/P010288/1Wellcome Trust 106239/Z/14/AWellcome Trust 106240/Z/14/ZWellcome Trust FC001043
6 · The paper itself

Abstract

Malaria parasites cause disease through repeated cycles of intraerythrocytic proliferation. Within each cycle, several rounds of DNA replication produce multinucleated forms, called schizonts, that undergo segmentation to form daughter merozoites. Upon rupture of the infected cell, the merozoites egress to invade new erythrocytes and repeat the cycle. In human malarial infections, an antibody response specific for the

Indexed as

Antigens, ProtozoanCell DivisionErythrocytesHumansMerozoitesPhosphorylationPlasmodium falciparumProspective StudiesProtozoan ProteinsSchizontsAntigens, ProtozoanProtozoan ProteinsCENP-CegressmalariaPlasmodium falciparumschizogonySEA1

Identifiers

PMID33688001
PMCPMC8092294
OpenAlexW3133746568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.