Evidence map›Paper›PMID 33687998›Full record

ArticleLife science alliance2021

Arterial stiffness and cardiac dysfunction in Hutchinson-Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase.

Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ryan von KleeckDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8085-5815
Emilia RobertsDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Paola CastagninoDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Kyle BruunDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Sonja A BrankovicDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth A HawthorneDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Tina XuDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
John W TobiasPenn Genomic Analysis Core and University of Pennsylvania, Philadelphia, PA, USA.
Richard K AssoianDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA assoian@pennmedicine.upenn.edu.ORCID 0000-0001-7635-6204
Translational Therapeutics (United States) · USUniversity of Pennsylvania · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Multidisciplinary Training in Cardiovascular BiologyT32HL007954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVIES, PETER FRANCIS · 2000 to 2019
$9.9M
Aging, gender and arterial stiffness in atherosclerosisR01AG047373 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ASSOIAN, RICHARD · 2014 to 2018
$2.2M
Arterial stiffening and SMC mechanobiology in Hutchinson-Guilford Progeria SyndromeR01AG062140 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ASSOIAN, RICHARD · 2019 to 2023
$2.0M
Arterial Stiffening and Mechanics in Hutchinson-Gilford Progeria SyndromeF31HL142160 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VON KLEECK, RYAN · 2018 to 2020
$118k
NHLBI NIH HHS F31 HL142160NHLBI NIH HHS T32 HL007954NIA NIH HHS R01 AG047373NIA NIH HHS R01 AG062140NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

Arterial stiffening and cardiac dysfunction are hallmarks of premature aging in Hutchinson-Gilford Progeria Syndrome (HGPS), but the molecular regulators remain unknown. Here, we show that the LaminA

Indexed as

Aging, PrematureAminopropionitrileAnimalsDisease Models, AnimalFemaleHeart DiseasesLamin Type AMaleMiceMice, Inbred C57BLMicroRNAsProgeriaProtein-Lysine 6-OxidaseVascular StiffnessAminopropionitrileLamin Type AMicroRNAsMIRN145 microRNA, humanProtein-Lysine 6-Oxidase

Identifiers

PMID33687998
PMCPMC8008950
OpenAlexW3134212456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.