Evidence map›Paper›PMID 33687983›Full record

ArticleBJGP open2021

Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review.

Ketaki Bhate, Liang-Yu Lin, John S Barbieri, Clémence Leyrat, Susan Hopkins, Richard Stabler, Laura Shallcross, Liam Smeeth, Nick Francis, Rohini Mathur and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJGP open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. One Health Determinants ofInternational journal of molecular sciences · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Characterization ofMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Ketaki BhateFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK ketaki.bhate@lshtm.ac.uk.ORCID https://orcid.org/0000-0001-5509-4428
Liang-Yu LinFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0003-4720-6738
John S BarbieriUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-5467-4102
Clémence LeyratFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-4097-4577
Susan HopkinsAMR Division, Public Health England, London, UK.ORCID https://orcid.org/0000-0001-5179-5702
Richard StablerFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-2402-6630
Laura ShallcrossFaculty of Population Health Sciences, University College London, London, UK.ORCID https://orcid.org/0000-0003-1713-2555
Liam SmeethFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-9168-6022
Nick FrancisSchool of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-8939-7312
Rohini MathurFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-3817-8790
Sinéad M LanganFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-7022-7441
Sarah-Jo SinnottFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0001-7586-686X
University of London · GBInstitute of Population and Public Health · CALondon School of Hygiene & Tropical Medicine · GBPrimary Health Care · QAPublic Health England · GBUniversity of Pennsylvania · US

Funding

Department of Health DRF-2018-11-ST2-066Medical Research Council MR/T032448/1Wellcome Trust 205039/Z/16/Z
6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) is a global health priority. Acne vulgaris is a common skin condition for which antibiotic use ranges from a few months to years of daily exposure.

aimTo systemically search for and synthesise evidence on the risk of treatment-resistant infections, and other evidence of AMR, following long-term oral antibiotic use for acne. DESIGN &

settingIn this systematic review, a literature search was carried out using the databases Embase, MEDLINE, Cochrane, and Web of Science. They were searched using MeSH, Emtree, or other relevant terms, and followed a pre-registered protocol.

methodSearch strategies were developed with a librarian and undertaken in July 2019. All searches date from database inception. The primary outcome was antibiotic treatment failure or infection caused by a resistant organism. Secondary outcomes included detection of resistant organisms without an infection, rate of infection, or changes to flora.

resultsA total of 6996 records were identified. Seventy-three full-text articles were shortlisted for full review, of which five were included. Two investigated rates of infection, and three resistance or changes to microbial flora. Three studies had 35 or fewer participants (range 20-118 496). Three studies had a serious or high risk of bias, one moderate, and one a low risk of bias. Weak evidence was found for an association between antibiotic use for acne and subsequent increased rates of upper respiratory tract infections and pharyngitis.

conclusionThere is a lack of high quality evidence on the relationship between oral antibiotics for acne treatment and subsequent AMR sequelae. This needs to be urgently addressed with rigorously conducted studies.

Indexed as

acne vulgarisantibioticantimicrobial resistancedihydrofolate reductase inhibitormacrolidestetracycline

Identifiers

PMID33687983
PMCPMC8278499
OpenAlexW3133960014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.