ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 28 citations in OpenAlex.
- Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- [Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- GABAJournal of neurochemistry · 2024Review
- Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience.Nature communications · 2024Article
- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
- Shank3 Deficiency Results in a Reduction in GABAergic Postsynaptic Puncta in the Olfactory Brain Areas.Neurochemical research · 2024Article
- Olfactory Critical Periods: How Odor Exposure Shapes the Developing Brain in Mice and Flies.Biology · 2024Review
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Bulbar projecting subcortical GABAergic neurons send collateral branches extensively and selectively to primary olfactory cortical regions.The Journal of comparative neurology · 2023Article
- Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with GABAergic and DNA methyltransferase mRNAs in lymphocytes.Frontiers in psychiatry · 2023Article
- Long-range GABAergic projections contribute to cortical feedback control of sensory processing.Nature communications · 2022Article
- Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice.Communications biology · 2022Article
- Article
- αFrontiers in cellular neuroscience · 2022Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Lactate activates hypothalamic POMC neurons by intercellular signaling.Scientific reports · 2021Article
- Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior.Frontiers in cellular neuroscience · 2021Article
- Basal Forebrain Modulation of Olfactory CodingInternational journal of psychological researchArticle
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3 authors at 1 institution in 1 country.
Funding
Abstract
Local interneurons of the olfactory bulb (OB) are densely innervated by long-range GABAergic neurons from the basal forebrain (BF), suggesting that this top-down inhibition regulates early processing in the olfactory system. However, how GABAergic inputs modulate the OB output neurons, the mitral/tufted cells, is unknown. Here, in male and female mice acute brain slices, we show that optogenetic activation of BF GABAergic inputs produced distinct local circuit effects that can influence the activity of mitral/tufted cells in the spatiotemporal domains. Activation of the GABAergic axons produced a fast disinhibition of mitral/tufted cells consistent with a rapid and synchronous release of GABA onto local interneurons in the glomerular and inframitral circuits of the OB, which also reduced the spike precision of mitral/tufted cells in response to simulated stimuli. In addition, BF GABAergic inhibition modulated local oscillations in a layer-specific manner. The intensity of locally evoked θ oscillations was decreased on activation of top-down inhibition in the glomerular circuit, while evoked γ oscillations were reduced by inhibition of granule cells. Furthermore, BF GABAergic input reduced dendrodendritic inhibition in mitral/tufted cells. Together, these results suggest that long-range GABAergic neurons from the BF are well suited to influence temporal and spatial aspects of processing by OB circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.