Evidence map›Paper›PMID 33687952›Full record

ArticleCancer research2021

Androgen Receptor Regulates CD44 Expression in Bladder Cancer.

Joseph L Sottnik, Lauren Vanderlinden, Molishree Joshi, Ana Chauca-Diaz, Charles Owens, Donna E Hansel, Colin Sempeck, Debashis Ghosh, Dan Theodorescu

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

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  12. Bladder cancer.Nature reviews. Disease primers · 2023
    Review
  13. The androgen receptor in bladder cancer.Nature reviews. Urology · 2023
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Joseph L SottnikDepartment of Pathology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-0263-3608
Lauren VanderlindenDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.
Molishree JoshiDepartment of Pharmacology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0003-4109-5918
Ana Chauca-DiazDepartment of Surgery, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.
Charles OwensDepartment of Surgery, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0003-0485-9317
Donna E HanselDepartment of Pathology & Laboratory Medicine, Oregon Health & Science University, Portland, Oregon.
Colin SempeckDepartment of Molecular Cellular & Developmental Biology, University of Colorado - Boulder, Boulder, Colorado.
Debashis GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado - Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-6618-1316
Dan TheodorescuDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California. dan.theodorescu@cshs.org.ORCID 0000-0002-8708-8206
University of Colorado Anschutz Medical Campus · USColorado School of Public Health · USCedars-Sinai Medical Center · USOregon Health & Science University · USUniversity of Colorado Boulder · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Understanding the RhoGDI2 metastasis suppressor geneR01CA143971 · NCI · UNIVERSITY OF COLORADO DENVER · PI THEODORESCU, DAN · 2010 to 2020
$4.4M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA143971
6 · The paper itself

Abstract

The androgen receptor (AR) is important in the development of both experimental and human bladder cancer. However, the role of AR in bladder cancer growth and progression is less clear, with literature indicating that more advanced stage and grade disease are associated with reduced AR expression. To determine the mechanisms underlying these relationships, we profiled AR-expressing human bladder cancer cells by AR chromatin immunoprecipitation sequencing and complementary transcriptomic approaches in response to

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorCell ProliferationGene Expression ProfilingHumansHyaluronan ReceptorsMaleMiceMice, NudePrognosisReceptors, AndrogenTumor Cells, CulturedUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysAR protein, humanBiomarkers, TumorCD44 protein, humanHyaluronan ReceptorsReceptors, Androgen

Identifiers

PMID33687952
PMCPMC8782536
OpenAlexW3135571358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.