Evidence map›Paper›PMID 33687856›Full record

ArticleClinical endoscopy2021

Efficacy of Hypertonic Saline-Epinephrine Local Injection Around the Anal Side before Endoscopic Papillectomy for Ampullary Tumors.

Naoki Okano, Yoshinori Igarashi, Ken Ito, Saori Mizutani, Hiroki Nakagawa, Kouji Watanabe, Yuuto Yamada, Kensuke Yoshimoto, Yuusuke Kimura, Susumu Iwasaki and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Naoki OkanoDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Yoshinori IgarashiDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Ken ItoDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Saori MizutaniDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Hiroki NakagawaDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Kouji WatanabeDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Yuuto YamadaDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Kensuke YoshimotoDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Yuusuke KimuraDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Susumu IwasakiDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Kensuke TakumaDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Seiichi HaraDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Yuui KishimotoDivision of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Toho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsBleeding is a complication of endoscopic snare papillectomy for ampullary tumors. This study aimed to investigate the clinical efficacy of hypertonic saline-epinephrine (HSE) local injection before endoscopic papillectomy for prevention of bleeding.

methodsWe retrospectively reviewed the data of 107 consecutive patients with ampullary tumors who underwent endoscopic papillectomy. The rates of en bloc resection, pathological resection margins, and prevention of immediate or delayed bleeding in the simple snaring resection group (Group A) and the HSE injection group (Group B) were compared.

resultsA total of 44 and 63 patients were enrolled in Groups A and B, respectively. The total complete resection rate was 89.7% (96/107); the clinical complete resection rates in Group A and Group B were 86.3% (38/44) and 92.1% (58/63), respectively (p=0.354). Post-papillectomy bleeding occurred in 22 patients. In Groups A and B, the immediate bleeding rates were 20.5% (9/44) and 4.8% (3/63), respectively (p=0.0255), while the delayed bleeding rates were 7% (3/44) and 11% (7/63), respectively (p=0.52). The rates of positive horizontal and vertical pathological margin in both groups were 27% and 16%, respectively.

conclusionHSE local injection was effective in preventing immediate bleeding and was useful for safely performing endoscopic papillectomy for ampullary tumors.

Indexed as

Ampullary tumorComplicationEndoscopic papillectomyLocal injection

Identifiers

PMID33687856
PMCPMC8505187
OpenAlexW3135237028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.