Evidence map›Paper›PMID 33687660›Full record

ArticleJournal of natural medicines2021

Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida.

Prema, Takeshi Kodama, Hnin Htet Wai Nyunt, Hla Ngwe, Ikuro Abe, Hiroyuki Morita

Abstract read
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Article in Journal of natural medicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integrative geno-metabolomics of tenasserim turmeric (Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

PremaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Takeshi KodamaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Hnin Htet Wai NyuntDepartment of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
Hla NgweDepartment of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
Ikuro AbeGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hiroyuki MoritaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan. hmorita@inm.u-toyama.ac.jp.ORCID http://orcid.org/0000-0001-9963-0587

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New copaene-type and nerolidol-type sesquiterpenoids, 7-hydroxymustakone (1) and 15-hydroxynerolidol (2), and a 15-norlabdane diterpenoid, kaempcandiol (3), together with four known compounds (4-7) were isolated from the chloroform extract of Kaempferia candida roots and rhizomes. The structures of the new compounds 1-3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The extract of the K. candida roots and rhizomes and all isolated compounds 1-7 possessed HIV-1 viral protein R (Vpr) inhibitory activities on the TREx-HeLa-Vpr cell line at a 5 μM concentration, without detectable cytotoxicity.

Indexed as

Antiviral AgentsDiterpenesHeLa CellsHIV-1HumansMolecular StructureMyanmarPhytochemicalsPlant RootsRhizomeSesquiterpenesvpr Gene Products, Human Immunodeficiency VirusZingiberaceaeAntiviral AgentsDiterpenesnerolidolPhytochemicalsSesquiterpenesvpr Gene Products, Human Immunodeficiency Virusvpr protein, Human immunodeficiency virus 1DiterpenoidsKaempferia candidaSesquiterpenoidsVpr

Identifiers

PMID33687660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.