Evidence map›Paper›PMID 33687646›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2021

Bruising: A Neglected, Though Patient-Relevant Complication of Insulin Injections Coming to Light from a Real-Life Nationwide Survey.

Sandro Gentile, Giuseppina Guarino, Teresa Della Corte, Giampiero Marino, Ersilia Satta, Carmine Romano, Carmelo Alfrone, Clelia Lmberti, Felice Strollo, AMD-OSDI Study Group

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Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Bruising-An Ignored Issue?Journal of diabetes science and technology · 2022
    Article
  4. Diabetes Technology Meeting 2021.Journal of diabetes science and technology · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sandro GentileDepartment of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy. s.gentile1949@gmail.com.ORCID http://orcid.org/0000-0002-9059-6121
Giuseppina GuarinoDepartment of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.
Teresa Della CorteDepartment of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.
Giampiero MarinoDepartment of Internal Medicine, Campania University "Luigi Vanvitelli", Naples, Italy.
Ersilia SattaNefrocenter Research Network & Nyx Start-Up, Naples, Italy.
Carmine RomanoNefrocenter Research Network & Nyx Start-Up, Naples, Italy.
Carmelo AlfroneNefrocenter Research Network & Nyx Start-Up, Naples, Italy.
Clelia LmbertiNefrocenter Research Network & Nyx Start-Up, Naples, Italy.
Felice StrolloEndocrinology and Diabetes, IRCCS San Raffaele Pisana, Rome, Italy.
AMD-OSDI Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite the availability of sophisticated devices and suitable recommendations on how to best perform insulin injections, lipohypertrophy (LH) and bruising (BR) frequently occur as a consequence of improper injection technique.

aimThe purpose of this nationwide survey was to check literature-reported LH risk factors or consequences for any association with BR

methodThis was a cross-sectional, observational, multicenter study based on the identification of skin lesions at all patient-reported insulin injection sites in 790 subjects with diabetes. General and injection habit-related elements were investigated as possible BR risk factors.

resultsWhile confirming the close relationship existing between LH and a full series of factors including missed injection site rotation, needle reuse, long-standing insulin treatment, frequent hypoglycemic events (hypos), and great glycemic variability (GV), the observed data could find no such association with BR, which anyhow came with high HbA1c levels, missed injection site rotation, and long-standing insulin treatment.

conclusionBR most likely depends on the patient's habit of pressing the injection pen hard onto the skin. Despite being worrisome and affecting quality of life, BR seems to represent a preliminary stage of LH but does not affect the rate of hypos and GV.

trial registration207/19.09.2017.

Indexed as

BruisingDiabetesInjection techniqueInsulinLipohypertophy

Identifiers

PMID33687646
PMCPMC7994491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.