ArticleJournal of cancer research and clinical oncology2021
Application of four nutritional risk indexes in perioperative management for esophageal cancer patients.
Article in Journal of cancer research and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Predictive role of geriatric nutritional risk index for postoperative complications in operated esophageal cancer patients: a meta-analysis.Journal of cardiothoracic surgery · 2025Pooled it
- Association of preoperative controlling nutritional status score with clinical outcomes among surgical patients with esophageal cancer: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Predictive value of geriatric nutritional risk index in patients with pancreatic cancer: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Do nutritional assessment tools (PNI, CONUT, GNRI) predict adverse events after spinal surgeries? A systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- The value of perioperative nutritional risk stratification in the prevention of surgical site infection: precision application from GLIM/PG-SGA to PNI, CONUT, and GNRI.Frontiers in nutrition · 2026Review
- Association between Geriatric Nutritional Risk Index (GNRI) and all-cause mortality in centenarians, with a focus on nonlinear and threshold effects: a multi-method observational study.Frontiers in nutrition · 2026Article
- Risk factors for postoperative intensive care unit admission after minimally invasive esophagectomy following neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma: a retrospective cohort study.Frontiers in oncology · 2026Article
- Trajectories of postoperative nutritional risk changes in patients with oesophageal cancer and their relationship with symptom recovery-a multicentre longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Prognostic value of nutritional risk index in esophageal cancer: A protocol for systematic review and meta-analysis.Medicine · 2025Article
- Association of immunonutritional indicators with all-cause mortality in adult stroke patients.Scientific reports · 2025Article
- Patterns of infectious complications and their implication on health system costs after esophagectomy for esophageal cancer: Real-world data from three European centers.Langenbeck's archives of surgery · 2025Article
- Association of malnutrition risk evaluated by the geriatric nutritional risk index with post-stroke myocardial injury among older patients with first‑ever ischemic stroke.BMC geriatrics · 2025Article
- Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer.BMC medicine · 2025Article
- Malnutrition risk, weight loss, and subsequent survival in patients listed for heart transplantation.JHLT open · 2025Article
- Observational
- Comparing 11 nutrition-inflammation indices for perioperative management and prognostic evaluation in non-small cell lung cancer patients.Frontiers in nutrition · 2025Article
- Preoperative NRI outperforms other time points in predicting prognosis of ESCC with neoadjuvant therapy.Frontiers in nutrition · 2025Article
- Malnutrition Prevalence and Its Implications on Surgical and Oncological Outcomes in Advanced Ovarian Cancer Patients: A Comprehensive Analysis.Obstetrics and gynecology international · 2025Article
- GLIM criteria-based identification of severe malnutrition and its relationship with the risk of mortality among older Chinese adults with arthritis or rheumatism.Journal of health, population, and nutrition · 2024Article
- The prognostic value of controlling nutritional status score on esophageal squamous cell carcinoma patients with neoadjuvant therapy followed by esophagectomy-a retrospective research.Journal of thoracic disease · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe Prognostic Nutritional Index (PNI), Nutritional Risk Index (NRI), Geriatric Nutritional Risk Index (GNRI), and Controlling Nutritional Status (CONUT) score were devised for quantifying nutritional risk. This study evaluated their properties in detecting compromised nutrition and guiding perioperative management of esophageal cancer patients.
methodsA prospective institutional database of esophageal cancer patients was reviewed and analyzed. Compromised nutritional status was defined as PNI < 50, NRI < 97.5, GNRI < 92, or CONUT score ≥ 4, respectively. The malnutrition diagnosis consensus established by the European Society of Clinical Nutrition and Metabolism (ESPEN 2015) was selected as reference. Multivariable logistic regression and receiver operating characteristic curve analysis were used. External validation was conducted.
resultsAfter reviewing the 212-patient database, 192 patients were finally included. Among the four nutritional indexes, the GNRI < 92 showed highest sensitivity (72.0%), specificity (78.9%), and consistency (AUC 0.754, 95% CI 0.672-0.836) with malnutrition diagnosed by ESPEN 2015. The GNRI < 92 showed comparable performance with ESPEN 2015 in recognizing decreased fat mass, fat-free mass, and skeletal muscle mass (all P < 0.01). Both the GNRI < 92 and ESPEN 2015 showed good property in predicting major complications, infectious complications, overall complications and delayed hospital discharge (all P < 0.01), better than PNI < 50, NRI < 97.5, and CONUT score ≥ 4. Regarding the external validation, a retrospective analysis of 155 esophageal cancer patients confirmed the better performance of GNRI < 92 in predicting perioperative morbidities than other 3 nutritional indexes.
conclusionThe GNRI was optimal in perioperative management of esophageal cancer patients among the four nutritional indexes and was an appropriate alternative to ESPEN 2015 for simplifying nutritional assessment.
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