ArticleCerebral cortex (New York, N.Y. : 1991)2021
Cognitive and Neural Correlates of Loneliness and Wisdom during Emotional Bias.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study.NPP - digital psychiatry and neuroscience · 2026Article
- Breath-Focused Mindfulness and Compassion Training in Parent-Child Dyads: Pilot Intervention Study.JMIR formative research · 2025Article
- Preliminary ERP evidence of the impact of loneliness on Stroop interference for socio-emotional stimuli.Frontiers in neuroscience · 2025Article
- Modulation of Posterior Default Mode Network Activity During Interoceptive Attention and Relation to Mindfulness.Biological psychiatry global open science · 2024Article
- Neural activity during inhibitory control predicts suicidal ideation with machine learning.NPP - digital psychiatry and neuroscience · 2024Article
- Resting state default mode network is associated with wise advising.Scientific reports · 2023Article
- Distinct neural activations correlate with maximization of reward magnitude versus frequency.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Exposure to loneliness cues reduces prosocial behavior: Evidence from N400 and P300.Frontiers in psychology · 2023Article
- Dissociable neural mechanisms of cognition and well-being in youth versus healthy aging.Psychology and aging · 2022Article
- Mental health care for older adults: recent advances and new directions in clinical practice and research.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Social contacts and loneliness affect the own age bias for emotional faces.Scientific reports · 2022Article
- Abbreviated San Diego Wisdom Scale (SD-WISE-7) and Jeste-Thomas Wisdom Index (JTWI).International psychogeriatrics · 2022Article
- Neurobiology of "Positive Psychiatry".Schizophrenia bulletin · 2022Article
- Personalized machine learning of depressed mood using wearables.Translational psychiatry · 2021Article
- Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study.Frontiers in psychiatry · 2021Article
- Hybrid Harmony: A Multi-Person Neurofeedback Application for Interpersonal Synchrony.Frontiers in neuroergonomics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Loneliness and wisdom have opposing impacts on health and well-being, yet their neuro-cognitive bases have never been simultaneously investigated. In this study of 147 healthy human subjects sampled across the adult lifespan, we simultaneously studied the cognitive and neural correlates of loneliness and wisdom in the context of an emotion bias task. Aligned with the social threat framework of loneliness, we found that loneliness was associated with reduced speed of processing when angry emotional stimuli were presented to bias cognition. In contrast, we found that wisdom was associated with greater speed of processing when happy emotions biased cognition. Source models of electroencephalographic data showed that loneliness was specifically associated with enhanced angry stimulus-driven theta activity in the left transverse temporal region of interest, which is located in the area of the temporoparietal junction (TPJ), while wisdom was specifically related to increased TPJ theta activity during happy stimulus processing. Additionally, enhanced attentiveness to threatening stimuli for lonelier individuals was observed as greater beta activity in left superior parietal cortex, while wisdom significantly related to enhanced happy stimulus-evoked alpha activity in the left insula. Our results demonstrate emotion-context driven modulations in cognitive neural circuits by loneliness versus wisdom.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.