ArticleRadiology2021
Cerebrovascular Reactivity Mapping Using Resting-State BOLD Functional MRI in Healthy Adults and Patients with Moyamoya Disease.
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Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
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49 citing papers in PubMed, 83 citations in OpenAlex.
- Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.Magnetic resonance in medicine · 2026Article
- Resting-state BOLD fMRI-derived cerebrovascular reactivity for detecting crossed cerebellar diaschisis.Neuroradiology · 2026Article
- Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.GeroScience · 2026Article
- Age differences in spontaneous cerebrovascular reactivity at rest.GeroScience · 2026Article
- Blood-brain barrier integrity and brain entropy in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2026Article
- Unusual Synchronous Arbitrary-Gate Doppler Spectra Enable Intraoperative Hemodynamic Warning of Cerebral Hyperperfusion Syndrome on Moyamoya Disease.CNS neuroscience & therapeutics · 2026Article
- Real-time phase-contrast MRI can be used to quantify cerebrovascular reserve capacity - a comparative study to neurovascular ultrasound in healthy subjects.Neuroimage. Reports · 2026Article
- Moyamoya Vasculopathy and Atypical Moyamoya-like Patterns: Insights into Diagnosis and Therapeutic Implications.NeuroSci · 2026Review
- Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke.bioRxiv : the preprint server for biology · 2026Article
- Advancing whole-brain BOLD functional MRI in humans at 10.5 T with motion-robust 3D echo-planar imaging, parallel transmission, and high-density radiofrequency receive coils.Magnetic resonance in medicine · 2026Article
- Molecular and multimodal biomarkers in Moyamoya disease: from pathogenic mechanisms to clinical translation.European journal of medical research · 2026Review
- Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion.Cerebral circulation - cognition and behavior · 2026Article
- Advances in cerebrovascular reserve function assessment for moyamoya disease.BMJ neurology open · 2026Review
- Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Moyamoya disease: epidemiology, clinical features, pathogenesis, diagnosis and therapeutic interventions.Molecular biomedicine · 2025Review
- Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery.Brain informatics · 2025Article
- Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia.Neurology · 2025Article
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
- Presenting cerebrovascular reactivity as a determinant of direct and indirect surgical revascularization success in North American patients with moyamoya vasculopathy.Journal of neurosurgery · 2025Article
- Functional MRI Signatures of Autonomic Physiology in Aging.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
10 authors at 1 institution in 1 country.
Peiying LiuFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0003-0830-5960
Gongkai LiuFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0002-5916-7345
Marco C PinhoFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0002-4645-1638
Zixuan LinFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).
Binu P ThomasFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0002-3882-3251
Melissa RundleFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).
Denise C ParkFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0003-2050-3513
Judy HuangFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0002-0675-1935
Babu G WelchFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).
Hanzhang LuFrom the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).ORCID 0000-0003-3871-1564
Johns Hopkins University · US
Funding
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1MNeuroimaging of Dedifferentiation and Memory Across the LifespanR37AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2006 to 2016
$8.5MDallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in CognitionRF1AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2017 to 2019
$7.1MNormalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6MAn integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7MNon-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6MIMAGERY,VISUAL MEMORY &AGING:A NEUROIMAGING APPROACHR01AG006265 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARK, DENISE CORTIS · 1985 to 2005
$2.6MMR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2MCalibration of fMRI in Emotional AgingR21AG061851 · NIA · JOHNS HOPKINS UNIVERSITY · PI LIU, PEIYING, LU, HANZHANG · 2019 to 2020
$465kDevelopment of techniques to map cerebrovascular reactivity with resting-state MRIR21NS100006 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LIU, PEIYING · 2017 to 2018
$450kGas-free cerebrovascular reactivity (CVR) MRI in vascular cognitive impairmentR56NS115771 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LIU, PEIYING · 2020 to 2020
$436kNIA NIH HHS R01 AG006265NIA NIH HHS R01 AG064792NIA NIH HHS R21 AG061851NIA NIH HHS R37 AG006265NIA NIH HHS RF1 AG006265NIBIB NIH HHS P41 EB015909NIMH NIH HHS R01 MH084021NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS R21 NS100006NINDS NIH HHS R56 NS115771
Abstract
Background Cerebrovascular reserve, the potential capacity of brain tissue to receive more blood flow when needed, is a desirable marker in evaluating ischemic risk. However, current measurement methods require acetazolamide injection or hypercapnia challenge, prompting a clinical need for resting-state (RS) blood oxygen level-dependent (BOLD) functional MRI data to measure cerebrovascular reactivity (CVR). Purpose To optimize and evaluate an RS CVR MRI technique and demonstrate its relationship to neurosurgical treatment. Materials and Methods In this HIPAA-compliant study, RS BOLD functional MRI data collected in 170 healthy controls between December 2008 and September 2010 were retrospectively evaluated to identify the optimal frequency range of temporal filtering on the basis of spatial correlation with the reference standard CVR map obtained with CO
Indexed as
Cerebrovascular CirculationAdultBrain MappingCase-Control StudiesFemaleHumansImage EnhancementMagnetic Resonance ImagingMaleMiddle AgedMoyamoya DiseaseProspective StudiesRetrospective Studies
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