Evidence map›Paper›PMID 33687211›Full record

ArticleAnalytical chemistry2021

Ultra-High-Resolution IonStar Strategy Enhancing Accuracy and Precision of MS1-Based Proteomics and an Extensive Comparison with State-of-the-Art SWATH-MS in Large-Cohort Quantification.

Xue Wang, Liang Jin, Chenqi Hu, Shichen Shen, Shuo Qian, Min Ma, Xiaoyu Zhu, Fengzhi Li, Jianmin Wang, Yu Tian and 1 more

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Proceedings of the National Academy of Sciences of the United States of America · 2026
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  6. Translational control byRNA (New York, N.Y.) · 2023
    Article
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  8. Species-Deconvolved Proteomics forJournal of proteome research · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xue WangDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.
Liang JinAbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States.ORCID 0000-0002-8659-0536
Chenqi HuAbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States.
Shichen ShenDepartment of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States.
Shuo QianDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.
Min MaDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.
Xiaoyu ZhuDepartment of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States.
Fengzhi LiDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.
Yu TianAbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States.
Jun QuDepartment of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, United States.ORCID 0000-0002-1346-6809
Roswell Park Comprehensive Cancer Center · USAbbVie (United States) · USUniversity at Buffalo, State University of New York · US

Funding

Systems Biology of GlycosylationR01HL103411 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2011 to 2025
$7.1M
Multiplex Mass Spectrometric Protein Assays for Precise Monitoring of the Pathophysiology of ObesityU01DK124020 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI QIAN, WEI-JUN · 2019 to 2022
$3.3M
NHLBI NIH HHS R01 HL103411NIDDK NIH HHS U01 DK124020
6 · The paper itself

Abstract

Quantitative proteomics in large cohorts is highly valuable for clinical/pharmaceutical investigations but often suffers from severely compromised reliability, accuracy, and reproducibility. Here, we describe an ultra-high-resolution IonStar method achieving reproducible protein measurement in large cohorts while minimizing the ratio compression problem, by taking advantage of the exceptional selectivity of ultra-high-resolution (UHR)-MS1 detection (240k_FWHM@

Indexed as

ProteomicsTandem Mass SpectrometryCohort StudiesProteomeReproducibility of ResultsProteome

Identifiers

PMID33687211
PMCPMC10666926
OpenAlexW3134564264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.