ArticleAging2021
Early-onset of type 2 diabetes mellitus is a risk factor for diabetic nephropathy progression: a biopsy-based study.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- A call to action: A consensus statement on knowledge gaps and research priorities on the management of women with early onset type 2 diabetes in the preconception, pregnancy and postnatal periods: A report from the Diabetic Medicine Symposium at the Diabetes UK Annual Professional Conference, 2025.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Correlation between TyG index, TyG-BMI index and AIP index and early-onset type 2 diabetic nephropathy.Frontiers in endocrinology · 2026Article
- Differences in cardiovascular disease incidence according to changes in obesity status in young diabetic patients.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Global, regional, and national burden of diabetes and kidney diseases, 1990-2021: a trend and health inequality analyses based on the Global Burden of Disease Study 2021.Renal failure · 2025Article
- Association between age at diabetes diagnosis and the development and progression of diabetic retinopathy.Scientific reports · 2025Article
- Profiling of Macrovascular and Microvascular Complications in Young-Onset Type 2 Diabetes: A Scoping Review.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Molecular Basis of Cardiomyopathies in Type 2 Diabetes.International journal of molecular sciences · 2024Review
- A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Association of Bedtime with Early-Onset Diabetes and Islet Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.Nature and science of sleep · 2023Article
- Associations of serum amyloid A and 25-hydroxyvitamin D with diabetic nephropathy: A cross-sectional study.Journal of clinical laboratory analysis · 2022Article
- Article
- The Aggressive Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes: Pathogenetic Mechanisms and Potential Therapies.Medicina (Kaunas, Lithuania) · 2021Review
- Protective Effect of Keluoxin against Diabetic Nephropathy in Type 2 Diabetic Mellitus Models.Evidence-based complementary and alternative medicine : eCAM · 2021Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies show that patients with early-onset diabetes have higher risk of diabetic complications than those diagnosed in middle age. However, whether early-onset of type 2 diabetes mellitus (T2DM) is a risk factor for diabetic nephropathy (DN) progression remains unclear, especially a lack of data in biopsy-confirmed cohort. In This study, we enrolled 257 patients with T2DM and biopsy-confirmed DN to investigate the role of early-onset T2DM in DN progression. Participants were divided into two groups according to the age of T2DM diagnosis: early-onset group (less than 40 years) and later-onset group (40 years or older). We found that patients with early-onset T2DM had higher glomerular grades and arteriolar hyalinosis scores than those in later-onset group. After adjusted for confounding factors, early-onset of T2DM remained an independent predictor of end-stage renal disease (ESRD) for patients with DN. In conclusion, although with the comparable renal function and proteinuria, patients with early-onset T2DM and DN had worse renal pathological changes than those with later-onset. Early-onset of T2DM might be an important predictor of ESRD for patients with DN, which called more attention to early supervision and prevention for patients with early-onset T2DM and DN.
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