Evidence map›Paper›PMID 33686743›Full record

ArticleChemMedChem2021

Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme.

Rebecca N Adamek, Caitlin N Suire, Ryjul W Stokes, Monica K Brizuela, Seth M Cohen, Malcolm A Leissring

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca N AdamekDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Caitlin N SuireInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Ryjul W StokesDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Monica K BrizuelaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5233-2280
Malcolm A LeissringInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
University of California, Irvine · USUniversity of California San Diego · US

Funding

Zinc-targeting inhibitors of insulin-degrading enzymeR01GM115617 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEISSRING, MALCOLM A · 2016 to 2020
$1.4M
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
Graduate Research Fellowship Program (GRFP) from the National Science Foundation DGE-1650112NIGMS NIH HHS R01 GM115617NIGMS NIH HHS T32 GM112584U.C. San Diego Chemistry and Biochemistry Mass Spectrometry Facility
6 · The paper itself

Abstract

Insulin-degrading enzyme (IDE) is a human mononuclear Zn

Indexed as

Enzyme InhibitorsHumansInsulysinModels, MolecularMolecular StructurePyridinesThionesEnzyme InhibitorsInsulysinPyridinesThionesfragment-based drug discoveryhigh-throughput screeninginsulin-degrading enzymesmedicinal chemistrymetalloenzymes

Identifiers

PMID33686743
PMCPMC8627785
OpenAlexW3134546576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.