SynthesisInternational wound journal2021
Livedoid vasculopathy and its association with genetic variants: A systematic review.
Synthesis in International wound journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Livedoid vasculopathy - A diagnostic and therapeutic challenge.Frontiers in medicine · 2022Pooled it
- Livedoid vasculopathy and its association with genetic variants: A systematic review.International wound journal · 2021Pooled it
- Recurrent painful blisters over the right foot.JAAD case reports · 2025Article
- Clinical Characteristics and Disease Course of Livedoid Vasculopathy: A 10-Year Retrospective Analysis.Clinical, cosmetic and investigational dermatology · 2025Article
- A case report and literature review of livedoid vasculopathy in children.Frontiers in pediatrics · 2025Article
- Association betweenInternational journal of molecular sciences · 2023Article
- A case of a recalcitrant painful skin ulceration.International journal of dermatology · 2023Article
- Cutaneous Ulcer Caused by Apixaban Treatment Is Resolved after Replacement with Dabigatran.Medicina (Kaunas, Lithuania) · 2022Article
- A comprehensive review on pathogenesis, associations, clinical findings, and treatment of livedoid vasculopathy.Frontiers in medicine · 2022Review
- Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.International journal of women's dermatology · 2021Review
- Livedoid vasculopathy, calciphylaxis, and Martorell's hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs.Anais brasileiros de dermatologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Livedoid vasculopathy (LV) is considered a disease of hypercoagulability. Association of LV with genetic variants is poorly characterised and large-scale genetic association studies have not been performed. The aim of the study was to systematically review variants in LV patients and to analyse the available clinical data. A systematic search of the literature in PubMed and Embase databases was performed to identify articles investigating genetic variation in LV patients. Thirty studies or case reports were identified that reported 265 LV patients tested for at least one out of six genetic variations. Among them, PAI-1 -675 4G/5G was the most common, accounting for 85.26% (81/95). Heterozygous 4G/5G was the major genotype. PAI-1 A844G, MTHFR C677T, and MTHFR A1298C were the second, third, and fourth most common variants in LV patients. Prothrombin G20210A and Factor V G1691A were mainly present in LV patients from Europe, North America, and South America. This review highlights the associations between LV and genetic variants. The distribution of variants may be geographically or ethnicity dependent; however, large sample case-control studies are needed to clarify associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.