Evidence map›Paper›PMID 33686663›Full record

ArticleJournal of anatomy2021

Major urinary protein excreted in rodent hindpaw sweat.

Trevor Poitras, Ramanaguru Siva Piragasam, Twinkle Joy, Jesse Jackson, Ambika Chandrasekhar, Richard Fahlman, Douglas W Zochodne

Open access · greenAbstract read
In one paragraph

Article in Journal of anatomy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Trevor PoitrasDivision of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Ramanaguru Siva PiragasamDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Twinkle JoyDivision of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Jesse JacksonDepartment of Physiology and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Ambika ChandrasekharDivision of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Richard FahlmanDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Douglas W ZochodneDivision of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-1692-5983
University of Alberta · CA

Funding

CIHR FRN148675
6 · The paper itself

Abstract

Alternative roles for sweat production beyond thermoregulation, considered less frequently, include chemical signaling. We identified the presence of a well-established rodent urinary pheromone, major urinary protein (MUP) in sweat ductules of the footpad dermal skin of mice. A hindpaw sweat proteomic analysis in hindpaw sweat samples collected in rats and generated by unmyelinated axon activation, identified seven lipocalin family members including MUP and 19 additional unique proteins. Behavioural responses to sniffing male mouse foot protein lysates suggested avoidance in a subset of male mice, but were not definitive. Rodent hindpaw sweat glands secrete a repertoire of proteins that include MUPs known to have roles in olfactory communication.

Indexed as

Animal CommunicationAnimalsHindlimbMaleMiceProteinsRatsRats, Sprague-DawleySweatmajor urinary proteinsProteinslipocalinsMUPs (major urinary proteins)pheromonesweatsweat glands

Identifiers

PMID33686663
PMCPMC8273588
OpenAlexW3134890763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.