Observational studyJournal of endocrinological investigation2021
Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.
Observational study in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of a two-week modified ketogenic diet on circulating lipoprotein subclasses, GDF15, and FGF21 in obese adults.Journal of translational medicine · 2025Trial
- Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.Journal of endocrinological investigation · 2026Article
- Sex-Specific Cytokine Responses and Metabolic Adaptation to Weight Loss in Obesity with Insulin Resistance.Nutrients · 2026Observational
- An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation.npj aging · 2026Article
- Impact of including weekend days on dietary intake patterns in Korean adults with metabolic syndrome: a secondary data analysis.Journal of Korean biological nursing science · 2026Article
- Bottlenose Dolphin (Tursiops truncatus) Metabolic Rate in Relation to Reduced Energy Acquisition.Integrative and comparative biology · 2026Article
- Stress-induced IL-6 regulation in pediatric bone growth disorders: current insights and therapeutic strategies.Frontiers in endocrinology · 2026Review
- Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species.Frontiers in genetics · 2026Review
- The Mediterranean Diet in Primary and Secondary Prevention of Coronary Heart Disease: Evidence and Mechanisms.Nutrients · 2025Review
- Relationship Between Dietary Inflammatory Index, Diets, and Cardiovascular Medication.Nutrients · 2025Article
- Review
- Effects of weight loss and weight gain on HbABMJ open · 2025Observational
- Time-Restricted Eating Versus Daily Calorie Restriction: Effects on Inflammatory Markers over 12 Months in Adults with Obesity.Nutrients · 2025Article
- The impact of intermittent fasting on fertility: A focus on polycystic ovary syndrome and reproductive outcomes in Women-A systematic review.Metabolism open · 2025Review
- Changes in Cytokines and Fibrotic Growth Factors after Low-Carbohydrate or Low-Fat Low-Energy Diets in Females with Lipedema.Current developments in nutrition · 2025Article
- Platelet-to-high-density lipoprotein ratio as a biomarker for asthma risk in adolescents: insights from NHANES 2011-2023.Frontiers in allergy · 2025Article
- Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model.Frontiers in cellular neuroscience · 2025Article
- Effects of short-term very low-calorie diet on metabolic profile in patients with metabolic syndrome.Frontiers in endocrinology · 2025Article
- Effect of Diet on HDL in Obesity.Molecules (Basel, Switzerland) · 2024Review
- Temporal trends in the starting of insulin therapy in type 2 diabetes in Italy: data from the AMD Annals initiative.Journal of endocrinological investigation · 2024Article
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundWeight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid profiles in patients are still unclear.
aimTo determine the effects of diet-induced weight loss on metabolic parameters, lipids and cytokine profiles.
methodsEighteen adult males with metabolic syndrome (defined according to IDF 2009) and Body Mass Index (BMI) between 25 and 35 kg/m
resultsAfter weight loss, a significant improvement in BMI, waist circumference, insulin, fasting blood glucose and HOMA-IR (homeostasis model assessment of insulin resistance) was observed. The analysis of LDL (low-density lipoprotein cholesterol) and HDL (high-density lipoprotein cholesterol) lipoproteins showed a change in their composition with a massive transfer of triacylglycerols from HDL to LDL. This was associated with a significant reduction in peripheral pro-inflammatory cytokines such as IL-6, TNF-α, IL-8 and MIP-1β, leading to an overall decreased inflammatory score. An interesting positive correlation was also observed among peripheral cytokines levels after diet and peripheral levels of CETP (cholesteryl ester transfer protein), an enzyme with a key role in lipid change.
conclusionWeight loss through caloric restriction is associated with an improvement in peripheral lipid and cytokine profiles that may play a major role in improving cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.