Evidence map›Paper›PMID 33686610›Full record

Trial reportPharmacological reports : PR2021

Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies.

Piotr J Rudzki, Katarzyna Jarus-Dziedzic, Monika Filist, Edyta Gilant, Katarzyna Buś-Kwaśnik, Andrzej Leś, Małgorzata Sasinowska-Motyl, Łukasz Nagraba, Magdalena Bujalska-Zadrożny

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Piotr J RudzkiŁukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland.ORCID https://orcid.org/0000-0002-4622-4849
Katarzyna Jarus-DziedzicBioVirtus Research Site Sp, ul. Borowa 14/18, 05-400, Otwock, Poland.
Monika FilistŁukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland.
Edyta GilantŁukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland.
Katarzyna Buś-KwaśnikŁukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland.ORCID https://orcid.org/0000-0003-4484-7142
Andrzej LeśŁukasiewicz Research Network - Pharmaceutical Research Institute, ul. Rydygiera 8, 02-091, Warsaw, Poland.
Małgorzata Sasinowska-MotylDepartment of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland.
Łukasz NagrabaOrthopedic and Rehabilitation Department, Medical University of Warsaw, ul. Kondratowicza 8, 03-242, Warsaw, Poland.
Magdalena Bujalska-ZadrożnyDepartment of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, ul. Banacha 1b, 01-793, Warsaw, Poland. magdalena.bujalska@wum.edu.pl.ORCID http://orcid.org/0000-0002-4270-6373
Łukasiewicz Research Network · PLMedical University of Warsaw · PLBioVirtus (Poland) · PL

Funding

Narodowe Centrum Badań i Rozwoju INNOTECH-K2IN2/70/183154/NCBR/13
6 · The paper itself

Abstract

backgroundMagnesium ions (Mg

methodsTramadol was administered to healthy Caucasian subjects with and without Mg

resultsA total of 25 and 26 subjects completed the single- and multiple-dose study, respectively. Both primary and secondary pharmacokinetic parameters were similar. The 90% confidence intervals for C

conclusionsThe absence of Mg

Indexed as

Administration, OralAdultAnalgesics, OpioidArea Under CurveCross-Over StudiesDose-Response Relationship, DrugDrug Administration ScheduleDrug InteractionsFemaleHumansMagnesiumMaleTramadolYoung AdultAnalgesics, OpioidMagnesiumO-demethyltramadolTramadolDrug interactionO-DesmethyltramadolOpioid analgesiaPain treatmentPharmacokineticsTramadol

Identifiers

PMID33686610
PMCPMC7994227
OpenAlexW3134841325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.