Evidence map›Paper›PMID 33686474›Full record

ArticleEuropean radiology2021

The role of the deep convolutional neural network as an aid to interpreting brain [

Arnoldo Piccardo, Roberto Cappuccio, Gianluca Bottoni, Diego Cecchin, Luca Mazzella, Alessio Cirone, Sergio Righi, Martina Ugolini, Pietro Bianchi, Pietro Bertolaccini and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Detection of parkinson's disease with neuroimaging modalities using machine learning and artificial intelligence: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Relevance ofEJNMMI research · 2023
    Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Arnoldo PiccardoDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura delle Cappuccine 14, 16128, Genoa, Italy. arnoldo.piccardo@galliera.it.ORCID http://orcid.org/0000-0002-6779-1471
Roberto CappuccioI.N.F.N. - Section of Pisa, Pisa, Italy.
Gianluca BottoniDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura delle Cappuccine 14, 16128, Genoa, Italy.
Diego CecchinDepartment of Medicine - DIMED, University-Hospital of Padova, Padova, Italy.
Luca MazzellaDepartment of Neurology, ASL 3 di Genova, Genova, Italy.
Alessio CironeMedical Physics Department, E.O. "Ospedali Galliera", Genoa, Italy.
Sergio RighiMedical Physics Department, E.O. "Ospedali Galliera", Genoa, Italy.
Martina UgoliniDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura delle Cappuccine 14, 16128, Genoa, Italy.
Pietro BianchiDepartment of Nuclear Medicine of Massa Carrara, Azienda USL Toscana NordOvest, Pisa, Italy.
Pietro BertolacciniDepartment of Nuclear Medicine of Massa Carrara, Azienda USL Toscana NordOvest, Pisa, Italy.
Elena LorenziniDepartment of Nuclear Medicine of Massa Carrara, Azienda USL Toscana NordOvest, Pisa, Italy.
Michela MassolloDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura delle Cappuccine 14, 16128, Genoa, Italy.
Antonio CastaldiDepartment of Neuroradiology, E.O. "Ospedali Galliera", Genoa, Italy.
Francesco FizNuclear Medicine Unit, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
Laura StradaDepartment of Neurology, E.O. "Ospedali Galliera", Genoa, Italy.
Angelina CistaroDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura delle Cappuccine 14, 16128, Genoa, Italy.
Massimo Del SetteDepartment of Neurology, E.O. "Ospedali Galliera", Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo test the performance of a 3D convolutional neural network (CNN) in analysing brain [

methodsWe analyzed patients who had undergone [

resultsNinety-eight patients were enrolled: 43 presented nigro-striatal degeneration and 55 negative cases used as controls. After training on 69 patients, the diagnostic performance of the 3D CNN was then calculated in 29 patients. Sensitivity, specificity, negative predictive value, positive predictive value and accuracy were 100%, 89%, 100%, 85% and 93%, respectively. When we compared the 3D CNN results with the SOR analysis, we found that the two patients falsely classified as positive by the 3D CNN procedure showed SOR values ≤ 5

conclusions3D CNNs are able to interpret [ KEY POINTS: • [

Indexed as

Parkinson DiseasePositron Emission Tomography Computed TomographyBrainDihydroxyphenylalanineHumansNeural Networks, ComputerDihydroxyphenylalanine18F-DOPAConvolutional neural networksParkinson’s diseasePET/CT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.