Observational studyThe Journal of clinical endocrinology and metabolism2021
Primary Ovarian Insufficiency in Women With Addison's Disease.
Observational study in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Autoimmune adrenalitis and an adrenal tumor: a rare cause of elevated 17-hydroxyprogesterone and secondary amenorrhea.JCEM case reports · 2026Article
- Inflammatory bowel disease leads to long-term ovarian dysfunction via immune-mediated follicular aging.Cellular and molecular life sciences : CMLS · 2026Article
- Adrenal crisis: incidence, clinical presentation and risk factors in patients with Addison's disease.Endocrine · 2025Article
- Changing Etiological Spectrum of Premature Ovarian Insufficiency over the Past Decades: A Comparative Analysis of Two Cohorts from a Single Center.Diagnostics (Basel, Switzerland) · 2025Article
- The risk factors, pathogenesis and treatment of premature ovarian insufficiency.Journal of ovarian research · 2025Review
- Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway.Translational oncology · 2025Article
- Role of epigenetic regulation in diminished ovarian reserve.Journal of assisted reproduction and genetics · 2025Review
- Investigation of the Causal Relationship Between Autoimmune Diseases and Premature Ovarian Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Aire Mutations and Autoimmune Diseases.Advances in experimental medicine and biology · 2025Review
- Female fertility and pregnancy in autoimmune Addison's disease - a mini review.Frontiers in endocrinology · 2025Review
- Primary Ovarian Insufficiency, Bone Health, and Other Outcomes in Adolescents.Obstetrics and gynecology clinics of North America · 2024Review
- Premature ovarian insufficiency.Nature reviews. Disease primers · 2024Review
- Diagnostic Value of Autoantibodies against Steroidogenic Enzymes and Hormones in Infertile Women with Premature Ovarian Insufficiency.International journal of molecular sciences · 2024Article
- Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis.Archives of gynecology and obstetrics · 2024Article
- Fertility and pregnancy in adrenal insufficiency.Endocrine connections · 2024Review
- Improving diagnostic precision in primary ovarian insufficiency using comprehensive genetic and autoantibody testing.Human reproduction (Oxford, England) · 2024Article
- Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Approach to the Patient: Diagnosis of Primary Adrenal Insufficiency in Adults.The Journal of clinical endocrinology and metabolism · 2023Article
- Ovarian Volume of Saudi Children and Adolescents in the Southern Region Based on Ultrasound Imaging.Cureus · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPrimary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison's disease (AAD) than in the general population, but their clinical characteristics are insufficiently studied.
objectiveTo assess the prevalence of POI in a large cohort of women with AAD and describe clinical, immunological, and genetic characteristics.
methodsAn observational population-based cohort study of the Norwegian National Addison Registry. The Norwegian Prescription Database was used to assess prescription of menopausal hormone replacement therapy (HRT). A total of 461 women with AAD were studied. The primary outcome measure was prevalence of POI. Secondary outcomes were clinical characteristics, autoantibodies, and genome-wide single nucleotide polymorphism variation.
resultsThe prevalence of POI was 10.2% (47/461) and one-third developed POI before 30 years of age. POI preceded or coincided with AAD diagnosis in more than half of the women. The prevalence of concomitant autoimmune diseases was 72%, and AAD women with POI had more autoantibodies than AAD women without (≥2 autoantibodies in 78% vs 25%). Autoantibodies against side-chain cleavage enzyme (SCC) had the highest accuracy with a negative predictive value for POI of 96%. HRT use was high compared to the age adjusted normal population (11.3 % vs 0.7%).
conclusionOne in 10 women with AAD have POI. Autoantibodies against SCC are the most specific marker for autoimmune POI. We recommend testing women with AAD <40 years with menstrual disturbances or fertility concerns for autoantibodies against SCC.
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