ArticleInteractive cardiovascular and thoracic surgery2021
Blood metal levels after minimally invasive repair of pectus excavatum.
Article in Interactive cardiovascular and thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum.Pediatric surgery international · 2026Article
- [Adverse effects of metal exposure in pectus excavatum surgery].Anales del sistema sanitario de Navarra · 2025Article
- Preclinical and first-in-human safety studies on a novel magnetism-based haemofiltration method.Scientific reports · 2024Article
- Prediction of postoperative final degree and recurrence of pectus excavatum using machine learning algorithms.Journal of thoracic disease · 2024Article
- Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum.PloS one · 2023Article
- Nickel contamination after minimally-invasive repair of pectus excavatum persists after bar removal.PloS one · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMinimally invasive repair of pectus excavatum (MIRPE) is the most popular surgical approach for paediatric patients with pectus excavatum. A substernal stainless still bar is inserted and left in place for 3 years and then removed. Our goal was to investigate blood metal levels after MIRPE and to correlate them with surgical details, such as the numbers of bars and stabilizers and the length of time the bar was in place.
methodsBlood levels of iron, chromium, manganese, molybdenum and nickel were analysed in 130 teenagers (108 boys and 22 girls) who had MIRPE using inductively coupled plasma mass spectrometry. A total of 62 patients were operated on using MIRPE (study group) and 68 patients were evaluated at implant time (control group). Differences between the numbers of bars implanted and the presence or absence of stabilizers were also considered.
resultsSignificant increases in the levels of abnormal chromium were found in patients in the study group compared with the controls (P = 0.02). When we compared the group of patients with 2 or more bars with the group with 1 bar, the percentage of patients with a value above the threshold increased by 29 (P = 0.05). A significant increase in chromium levels was observed in patients with stabilizers (P = 0.03). Above-threshold levels of molybdenum were found in 5.1% of patients in the control group, but the number was not statistically significant (P = 0.09).
conclusionsWe demonstrated that stainless steel devices used in MIRPE can elevate blood metal levels in paediatric patients. Moreover, we demonstrated that the use of metal stabilizers is associated with higher metal levels, probably due to increased dispersion.
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