ArticleNature neuroscience2021
Gene-expression correlates of the oscillatory signatures supporting human episodic memory encoding.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- The genetic signature of memory encoding along the human hippocampal axis.bioRxiv : the preprint server for biology · 2026Article
- A transcriptional program associated with neurotransmission in the living human brain.Molecular psychiatry · 2026Article
- Article
- Human-unique brain cell clusters are associated with learning disorders and human episodic memory activity.Molecular psychiatry · 2025Article
- The gene expression signature of electrical stimulation in the human brain.bioRxiv : the preprint server for biology · 2024Article
- Review
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Review
- Speech Reception in Young Children with Autism Is Selectively Indexed by a Neural Oscillation Coupling Anomaly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.PLoS biology · 2023Article
- Decoding brain memory formation by single-cell RNA sequencing.Briefings in bioinformatics · 2022Article
- NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.Neuron · 2021Article
- Genes that give our brains their rhythms.Nature neuroscience · 2021Article
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10 authors.
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Abstract
In humans, brain oscillations support critical features of memory formation. However, understanding the molecular mechanisms underlying this activity remains a major challenge. Here, we measured memory-sensitive oscillations using intracranial electroencephalography recordings from the temporal cortex of patients performing an episodic memory task. When these patients subsequently underwent resection, we employed transcriptomics on the temporal cortex to link gene expression with brain oscillations and identified genes correlated with oscillatory signatures of memory formation across six frequency bands. A co-expression analysis isolated oscillatory signature-specific modules associated with neuropsychiatric disorders and ion channel activity, with highly correlated genes exhibiting strong connectivity within these modules. Using single-nucleus transcriptomics, we further revealed that these modules are enriched for specific classes of both excitatory and inhibitory neurons, and immunohistochemistry confirmed expression of highly correlated genes. This unprecedented dataset of patient-specific brain oscillations coupled to genomics unlocks new insights into the genetic mechanisms that support memory encoding.
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