ArticleNature immunology2021
Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program.
Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- d-serine as a metabolic immune checkpoint in the tumour microenvironment.EBioMedicine · 2026Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease.Biomedicines · 2025Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Pathways and mechanisms of CD4Trends in immunology · 2024Review
- Article
- Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis.Clinical and experimental immunology · 2023Article
- Regulatory T cells in the face of the intestinal microbiota.Nature reviews. Immunology · 2023Review
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- Downregulation of chemokine receptor 9 facilitates CD4Nature communications · 2023Article
- Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.The Journal of experimental medicine · 2023Article
- Transcriptional programming of CD4Science immunology · 2023Article
- Cytotoxic CD4 T cells in the mucosa and in cancer.Frontiers in immunology · 2023Review
- Localization and movement of Tregs in gastrointestinal tract: a systematic review.Inflammation and regeneration · 2022Review
- A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.Science (New York, N.Y.) · 2022Article
- Newly recruited intraepithelial Ly6AImmunity · 2022Article
- Immunity to enteric viruses.Immunity · 2022Review
- Fate-mapping mice: new tools and technology for immune discovery.Trends in immunology · 2022Review
- Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, we uncovered the molecular imprinting of gut epithelium on T cells. Transcriptionally, conventional and regulatory (T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.