ArticleCommunications biology2021
Brain pathology recapitulates physiology: A network meta-analysis.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.Human brain mapping · 2026Pooled it
- Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects.Psychological medicine · 2026Pooled it
- ALE meta-analyses of voxel-based morphometry studies: Parameter validation via large-scale simulations.NeuroImage · 2023Pooled it
- Co-alteration Network Architecture of Major Depressive Disorder: A Multi-modal Neuroimaging Assessment of Large-scale Disease Effects.Neuroinformatics · 2023Pooled it
- A co-alteration parceling of the cingulate cortex.Brain structure & function · 2022Pooled it
- Pooled it
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Mental time travel and insight in schizophrenia.Psychological medicine · 2025Review
- Thirty years of SPM-BrainMap synergy: making and mining coordinate-based literature.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The phobic brain: Morphometric features correctly classify individuals with small animal phobia.Psychophysiology · 2025Article
- Embracing variability in the search for biological mechanisms of psychiatric illness.Trends in cognitive sciences · 2025Review
- Development and validation of a mental hyperactivity questionnaire for the evaluation of chronic stress in higher education.BMC psychology · 2024Article
- Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders.Nature neuroscience · 2023Article
- Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.Nature communications · 2022Article
- Unifying framework for cognitive training interventions in brain aging.Ageing research reviews · 2022Review
- Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.Nature communications · 2022Article
- Modeling NeurodegenerationFrontiers in neuroinformatics · 2021Article
- Lesion covariance networks reveal proposed origins and pathways of diffuse gliomas.Brain communications · 2021Article
- Substance-Specific and Shared Gray Matter Signatures in Alcohol, Opioid, and Polysubstance Use Disorder.Frontiers in psychiatry · 2021Article
- Submaximal Exercise Provokes Increased Activation of the Anterior Default Mode Network During the Resting State as a Biomarker of Postexertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Network architecture is a brain-organizational motif present across spatial scales from cell assemblies to distributed systems. Structural pathology in some neurodegenerative disorders selectively afflicts a subset of functional networks, motivating the network degeneration hypothesis (NDH). Recent evidence suggests that structural pathology recapitulating physiology may be a general property of neuropsychiatric disorders. To test this possibility, we compared functional and structural network meta-analyses drawing upon the BrainMap database. The functional meta-analysis included results from >7,000 experiments of subjects performing >100 task paradigms; the structural meta-analysis included >2,000 experiments of patients with >40 brain disorders. Structure-function network concordance was high: 68% of networks matched (pFWE < 0.01), confirming the broader scope of NDH. This correspondence persisted across higher model orders. A positive linear association between disease and behavioral entropy (p = 0.0006;R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.