ArticleNature human behaviour2021
Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits.
Article in Nature human behaviour, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance.Translational psychiatry · 2022Pooled it
- A comprehensive analysis of global, regional, and national trends in anorexia nervosa burden (1990-2021) and projections to 2040: insights from the global burden of disease study 2021.Social psychiatry and psychiatric epidemiology · 2026Article
- Associations of ADHD genetic risk with objective and subjective economic wellbeing: evidence from Finnish population-based cohorts.Social psychiatry and psychiatric epidemiology · 2026Article
- Parental income and psychiatric disorders from age 10 to 40: a genetically informative population study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Polygenic Risks for Mood Disorders and Economic Well-being: Study of Finnish Cohorts.Depression and anxiety · 2026Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Symptoms of problematic alcohol use differ in their genetic associations with comorbid internalizing, externalizing, and neurodevelopmental psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- The causal effect of smoking on psychiatric disorders: an examination of brain volume as a potential pathway.Psychological medicine · 2025Article
- Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity.NPJ science of learning · 2025Article
- Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects.Molecular psychiatry · 2025Article
- Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Virtues as protective factors for adolescent mental health.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Article
- Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank.Nature human behaviour · 2025Article
- Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health.Schizophrenia bulletin · 2024Article
- The mediating role of behavioral risk factors in the pathway between childhood disadvantage and adult psychological distress in a Finnish employee cohort.Scientific reports · 2024Article
- Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity.bioRxiv : the preprint server for biology · 2024Article
- The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.Nature communications · 2024Article
- Risk factors and their association network for young adults' suicidality: a cross-sectional study.BMC public health · 2024Article
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Abstract
Epidemiological studies show high comorbidity between different mental health problems, indicating that individuals with a diagnosis of one disorder are more likely to develop other mental health problems. Genetic studies reveal substantial sharing of genetic factors across mental health traits. However, mental health is also genetically correlated with socio-economic status (SES), and it is therefore important to investigate and disentangle the genetic relationship between mental health and SES. We used summary statistics from large genome-wide association studies (average N ~ 160,000) to estimate the genetic overlap across nine psychiatric disorders and seven substance use traits and explored the genetic influence of three different indicators of SES. Using genomic structural equation modelling, we show significant changes in patterns of genetic correlations after partialling out SES-associated genetic variation. Our approach allows the separation of disease-specific genetic variation and genetic variation shared with SES, thereby improving our understanding of the genetic architecture of mental health.
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