Trial reportScientific reports2021
Decreased amygdala volume in adults after premature birth.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Habenula volume alterations in adults born very preterm.Scientific reports · 2026Article
- Covid-19 pandemic in children born very premature with dysexecutive disorders: impact of isolation measures and/or neurobehavioral phenotype? A cross sectional study.Pediatric research · 2026Article
- Sequelae of preterm birth over the lifespan: an exploratory analysis of behavioral problems in childhood and increased risk of major depression and anxiety in adulthood from a cohort study.EClinicalMedicine · 2025Article
- Predictive value of transcranial Doppler ultrasound for brain development and craniocerebral injury in premature infants.American journal of translational research · 2025Article
- Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.Pediatric research · 2024Article
- Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm.Brain structure & function · 2024Article
- Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.Brain structure & function · 2024Article
- Altered gray-to-white matter tissue contrast in preterm-born adults.CNS neuroscience & therapeutics · 2023Article
- Physiological responses and behavioural organization of very low birth weight infants during swaddled versus traditional weighing.Nursing open · 2023Article
- Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels.Scientific reports · 2023Article
- Article
- Aberrant allometric scaling of cortical folding in preterm-born adults.Brain communications · 2023Article
- The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation.Cells · 2022Review
- Lower hypothalamus subunit volumes link with impaired long-term body weight gain after preterm birth.Frontiers in endocrinology · 2022Article
- Within amygdala: Basolateral parts are selectively impaired in premature-born adults.NeuroImage. Clinical · 2021Article
- The effect of very preterm birth on the Five-Factor Model of personality traits: A meta-analysis of individual participant data.European journal of personalityArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this problem, we stated the following questions: first, are whole amygdala volumes reduced in premature-born adults? And second, as adult anxiety traits are often increased after prematurity and linked with amygdala structure, are alterations in amygdala associated with adults' anxiety traits after premature birth? We addressed these questions by automated amygdala segmentation of MRI volumes in 101 very premature-born adults (< 32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls at 26 years of age of a prospectively and longitudinally collected cohort. We found significantly lower whole amygdala volumes in premature-born adults. While premature-born adults had significantly higher T score for avoidant personality reflecting increased social anxiety trait, this trait was not correlated with amygdala volume alterations. Results demonstrate reduced amygdala volumes in premature born adults. Data suggest lasting effects of prematurity on amygdala structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.