ArticleScientific reports2021
Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Inflammatory markers as prognostic markers in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Article
- Associations of inflammation-related nutritional and metabolic status indices CAR and CTI with 90-day unfavorable functional outcomes in patients with acute ischemic stroke.Frontiers in nutrition · 2026Article
- Is the C reactive protein/albumin ratio a good tool for retinal vein occlusion?BMC ophthalmology · 2025Article
- Modified Naples Prognostic Score for Postoperative Prognostic Stratification in Patients with Oral Squamous Cell Carcinoma.Journal of inflammation research · 2025Article
- Simple biomarkers based on CRP and albumin predict clinical outcomes in adult patients with T-cell acute lymphoblastic leukaemia.Frontiers in nutrition · 2025Article
- Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis.Immunity & ageing : I & A · 2024Article
- Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life.Biomedicines · 2023Article
- Prognostic significance of pre- and post-treatment hematological biomarkers in patients with head and neck cancer treated with chemoradiotherapy.Scientific reports · 2023Article
- Association between the PreoperativeNutrients · 2022Article
- Clinical risk factors for severity and prognosis of antiresorptive agent-related osteonecrosis of the jaw: a retrospective observational study.Journal of bone and mineral metabolism · 2022Observational
- Utility of prognostic nutritional index and systemic immune-inflammation index in oral cancer treatment.BMC cancer · 2022Article
- RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study.Journal of inflammation research · 2022Article
- The Systemic Inflammation Response Index as an Independent Predictor of Survival in Breast Cancer Patients: A Retrospective Study.Frontiers in molecular biosciences · 2022Article
- Serum C-reactive protein/albumin ratio as a prognostic marker in oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The systemic inflammatory response is known to be associated with poor outcomes in patients with various types of cancer. The C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the prognostic value of inflammatory markers for patients with oral squamous cell carcinoma (OSCC). The study population included 205 patients treated with OSCC between 2013 and 2018. The primary predictor variable was the inflammatory markers. The primary outcome variable was overall survival (OS). Univariate and multivariate analyses were performed using a Cox proportional hazards model to identify independent prognostic factors. The CAR had the highest area under the curve (AUC) values compared with other markers in the receiver operating characteristic (ROC) curve analysis. The cutoff value for CAR was 0.032 (AUC 0.693, P < 0.001). There was a significant difference in OS when patients were stratified according to CAR, with 79.1% for CAR < 0.032 and 35% for CAR ≥ 0.032 (P < 0.001). Cox multivariate analysis identified independent predictive factors for OS: age (hazard ratio [HR] 2.155, 95% confidence interval [CI] 1.262-3.682; P = 0.005), stage (HR 3.031, 95% CI 1.576-5.827; P = 0.001), and CAR (HR 2.859, 95% CI 1.667-4.904; P < 0.001). CAR (≥ 0.032 vs. < 0.032) is a good prognostic marker in patients with OSCC in terms of age and stage.
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