Trial reportScientific reports2021
Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial.Nature communications · 2026Trial
- Longitudinal Analysis of the Intestinal Microbiota among a Cohort of Children in Rural and Urban Areas of Pakistan.Nutrients · 2023Trial
- Network topology of the gut microbiome associates with metabolic health in obesity.Nature communications · 2026Article
- A Scoping Review of Gut Dysbiosis and Malnutrition in Neurological Disorders: Implications, Indications, and Promising Therapeutic Approaches.Journal of clinical medicine · 2026Review
- Methanobrevibacter smithii activates immune microenvironment of intestinum tenue in a mouse model.Archives of microbiology · 2026Article
- The study on the identification of cross-boundary microbiome enterotypes between high-altitude and coastal populations and their predictive value.BMC microbiology · 2026Article
- Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis.Frontiers in immunology · 2026Article
- Gut microbiota signatures associated with lithium treatment and clinical response in patients with bipolar disorder.Frontiers in microbiology · 2026Article
- Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism.Gut microbes · 2025Article
- Comparing alignment and de-novo approaches for gut microbiota metagenomic data analysis reveals differences in taxonomic resolution and novel functional insights.Scientific reports · 2025Article
- Gut Microbiota α- and β-Diversity, but Not Dietary Patterns, Differ Between Underweight and Normal-Weight Japanese Women Aged 20-39 Years.Nutrients · 2025Observational
- Methanobrevibacter smithii strain U29 whole genome sequence delineates M. smithii intermediate cell variants.BMC research notes · 2025Article
- Article
- The functional landscape of the appendix microbiome under conditions of health and disease.Gut pathogens · 2025Review
- Human Milk Archaea Associated with Neonatal Gut Colonization and Its Co-Occurrence with Bacteria.Microorganisms · 2025Article
- Categorizing and characterizing intestinal dysbiosis: evaluating stool microbial test clinical utility.Frontiers in microbiomes · 2025Article
- Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review.Frontiers in nutrition · 2025Review
- Review
- Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions.Engineering in life sciences · 2024Review
- Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort.Nutrients · 2024Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case-control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (p < 0.0001). The predictive positive value for detection of M. smithii gradually increased with age in controls while decreasing in cases. Among children providing two samples with a negative first sample, no SAM children became positive, while this proportion was 2/4 in controls (p = 0.0015). This data suggests that gut dysbiosis in SAM is not an immaturity but rather features a loss of M. smithii. The addition of M. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.