Evidence map›Paper›PMID 33686077›Full record

ArticleNature communications2021

Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae.

Robert C Will, Thandavarayan Ramamurthy, Naresh Chand Sharma, Balaji Veeraraghavan, Lucky Sangal, Pradeep Haldar, Agila Kumari Pragasam, Karthick Vasudevan, Dhirendra Kumar, Bhabatosh Das and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Exoproteome and Surfaceome of ToxigenicJournal of proteome research · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Multidrug-resistant toxigenicMicrobial genomics · 2023
    Article
  16. Article
  17. Endemic erythromycin resistantMicrobial genomics · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Robert C Will *Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.ORCID 0000-0002-4230-5182
Thandavarayan Ramamurthy *Translational Health Science and Technology Institute, Faridabad, India.
Naresh Chand Sharma *Maharishi Valmiki Infectious Diseases Hospital, Delhi, India.
Balaji VeeraraghavanDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Lucky SangalWorld Health Organization, New Delhi, India.
Pradeep HaldarMinistry of Health and Family Welfare, Govt. of India, New Delhi, India.
Agila Kumari PragasamDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Karthick VasudevanDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Dhirendra KumarTranslational Health Science and Technology Institute, Faridabad, India.ORCID 0000-0002-8014-2521
Bhabatosh DasTranslational Health Science and Technology Institute, Faridabad, India.ORCID 0000-0002-2447-5380
Eva HeinzDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0003-4413-3756
Vyacheslav MelnikovGabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.ORCID 0000-0002-0825-7930
Stephen BakerDepartment of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.ORCID 0000-0003-1308-5755
Vartul SangalFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.ORCID 0000-0002-7405-8446
Gordon DouganDepartment of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.
Ankur MutrejaDepartment of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. am872@medschl.cam.ac.uk.ORCID 0000-0002-1118-8075
Translational Health Science and Technology Institute · INChristian Medical College, Vellore · INUniversity of Cambridge · GBGabrichevsky Institute of Epidemiology and Microbiology · RULiverpool School of Tropical Medicine · GBMinistry of Health and Family Welfare · INNorthumbria University · GBWorld Health Organization - India · IN

Funding

Department of Health NIHR200640Medical Research CouncilWorld Health Organization 001
6 · The paper itself

Abstract

Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene of 291 tox

Indexed as

Anti-Infective AgentsCorynebacterium diphtheriaeDiphtheriaDiphtheria ToxinDiphtheria ToxoidDrug Resistance, BacterialGenetic VariationGenome, BacterialGenomicsHumansIndiaMicrobial Sensitivity TestsPhylogenyPolymorphism, Single NucleotideAnti-Infective AgentsDiphtheria ToxinDiphtheria Toxoid

Identifiers

PMID33686077
PMCPMC7940655
OpenAlexW3135274765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.