ArticleNature communications2021
Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Preanalytical Workflow Establishment for Reproducible Clinical Blood-Based Infrared Molecular Fingerprinting.Analytical chemistry · 2026Article
- Evaluating the VOCORDER device for early disease detection through breath analysis: study protocol for a two-phase clinical study.BMJ open · 2026Article
- A methodological approach for complex mixture aqueous solution analysis by ATR-FTIR spectroscopy.Chinese herbal medicines · 2026Article
- Optical convolutional spectrometer.Nature photonics · 2026Article
- Toward Informative Representations of Blood-Based Infrared Spectra via Unsupervised Deep Learning.Journal of biophotonics · 2025Article
- Bridging Spectral Gaps: Cross-Device Model Generalization in Blood-Based Infrared Spectroscopy.Analytical chemistry · 2025Article
- Electric-Field Molecular Fingerprinting to Probe Cancer.ACS central science · 2025Article
- Integration of FTIR Spectroscopy and Machine Learning for Kidney Allograft Rejection: A Complementary Diagnostic Tool.Journal of clinical medicine · 2025Article
- Article
- The Perils of Molecular Interpretations from Vibrational Spectra of Complex Samples.Angewandte Chemie (International ed. in English) · 2024Review
- CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration.PNAS nexus · 2024Article
- Article
- Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening.Cell reports. Medicine · 2024Article
- Review
- A novel interpretable machine learning model approach for the prediction of TiOScientific reports · 2024Article
- Probing Blood Plasma Protein Glycosylation with Infrared Spectroscopy.Analytical chemistry · 2024Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- Limits and Prospects of Molecular Fingerprinting for Phenotyping Biological Systems Revealed throughAnalytical chemistry · 2023Article
- Upconversion time-stretch infrared spectroscopy.Light, science & applications · 2023Article
- Rapid Biomarker-Based Diagnosis of Fibromyalgia Syndrome and Related Rheumatologic Disorders by Portable FT-IR Spectroscopic Techniques.Biomedicines · 2023Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health state transitions are reflected in characteristic changes in the molecular composition of biofluids. Detecting these changes in parallel, across a broad spectrum of molecular species, could contribute to the detection of abnormal physiologies. Fingerprinting of biofluids by infrared vibrational spectroscopy offers that capacity. Whether its potential for health monitoring can indeed be exploited critically depends on how stable infrared molecular fingerprints (IMFs) of individuals prove to be over time. Here we report a proof-of-concept study that addresses this question. Using Fourier-transform infrared spectroscopy, we have fingerprinted blood serum and plasma samples from 31 healthy, non-symptomatic individuals, who were sampled up to 13 times over a period of 7 weeks and again after 6 months. The measurements were performed directly on liquid serum and plasma samples, yielding a time- and cost-effective workflow and a high degree of reproducibility. The resulting IMFs were found to be highly stable over clinically relevant time scales. Single measurements yielded a multiplicity of person-specific spectral markers, allowing individual molecular phenotypes to be detected and followed over time. This previously unknown temporal stability of individual biochemical fingerprints forms the basis for future applications of blood-based infrared spectral fingerprinting as a multiomics-based mode of health monitoring.
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