Evidence map›Paper›PMID 33686059›Full record

ReviewSignal transduction and targeted therapy2021

COVID-19 in early 2021: current status and looking forward.

Chengdi Wang, Zhoufeng Wang, Guangyu Wang, Johnson Yiu-Nam Lau, Kang Zhang, Weimin Li

5 registry-linked trialsAbstract readReview
In one paragraph

Review in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 128 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05508477 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

A Multicenter, Randomized, Double Blind, Controlled, Phase III Clinical Trial (Immunobridging Study) of Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) in Healthy Population Aged 18 Years and Above

TypeinterventionalSponsorDr. Soetomo General HospitalRan2022 to 2023Enrolled4,005ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsVaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg, CoronaVac Biofarma COVID-19 Vaccine
NCT05918939 early_phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) Vaccine as Heterologue Booster in Adult Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2022 to 2023Enrolled350ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsVaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg, CoronaVac Biofarma COVID-1 9 Vaccine 3 µg
NCT06259578 early_phase1unknown statusnot on this mapstarted 2024, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih - UNAIR SARS-CoV-2 (Vero Cell Inactivated)) Vaccine as Homologue Booster in Adult Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2024 to 2024Enrolled400ConditionsCOVID-19 Pandemic, COVID-19 Vaccines, COVID-19 Virus DiseaseArmsINAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg
NCT06272253 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih - UNAIR SARS-CoV-2 (Vero Cell Inactivated)) as Heterologue Booster in Adolescent Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2023 to 2024Enrolled250ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsINAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg
NCT06282692 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

An Open Label, Phase III Clinical Trial (Immunobridging Study) of INAVAC (Vaksin Merah Putih - UA-SARS CoV-2 (Vero Cell Inactivated)) in Healthy Population Aged 12 to 17 Years Old

TypeinterventionalSponsorDr. Soetomo General HospitalRan2023 to 2024Enrolled400ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsINAVAC (Vaksin Merah Putih - UA-SARS CoV-2 (Vero Cell Inactivated) 5 µg
3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Recent Advance Analysis of Recovery in Hospitalized People with COVID-19: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. RETRACTED: Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial.The American journal of tropical medicine and hygiene · 2021
    Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Green Villages, the Pandemic, and the Future of California Urbanism.International journal of environmental research and public health · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chengdi Wang *Department of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
Zhoufeng Wang *Department of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
Guangyu Wang *School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China.ORCID 0000-0003-1312-884X
Johnson Yiu-Nam LauDepartment of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China. johnsonynlau@aol.com.
Kang ZhangCenter for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology, and University Hospital, Macau, China. kang.zhang@gmail.com.
Weimin LiDepartment of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, West China Medical School, Sichuan University, Chengdu, China. weimi003@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first description of a coronavirus-related pneumonia outbreak in December 2019, the virus SARS-CoV-2 that causes the infection/disease (COVID-19) has evolved into a pandemic, and as of today, >100 million people globally in over 210 countries have been confirmed to have been infected and two million people have died of COVID-19. This brief review summarized what we have hitherto learned in the following areas: epidemiology, virology, and pathogenesis, diagnosis, use of artificial intelligence in assisting diagnosis, treatment, and vaccine development. As there are a number of parallel developments in each of these areas and some of the development and deployment were at unprecedented speed, we also provided some specific dates for certain development and milestones so that the readers can appreciate the timing of some of these critical events. Of note is the fact that there are diagnostics, antiviral drugs, and vaccines developed and approved by a regulatory within 1 year after the virus was discovered. As a number of developments were conducted in parallel, we also provided the specific dates of a number of critical events so that readers can appreciate the evolution of these research data and our understanding. The world is working together to combat this pandemic. This review also highlights the research and development directions in these areas that will evolve rapidly in the near future.

Indexed as

Artificial IntelligenceCOVID-19Diagnosis, Computer-AssistedPandemicsSARS-CoV-2Humans

Identifiers

PMID33686059
PMCPMC7938042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.