Evidence map›Paper›PMID 33685520›Full record

ArticleActa neuropathologica communications2021

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.

Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C Holland, Ryuji Hamamoto, Koichi Ichimura

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  8. Advances in the Treatment of Pediatric Brain Tumors.Children (Basel, Switzerland) · 2022
    Review
  9. Tumor Suppressive Role of theJournal of personalized medicine · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Tatsuya Ozawa *Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan. taozawa@ncc.go.jp.ORCID http://orcid.org/0000-0001-8424-1562
Syuzo Kaneko *Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan. sykaneko@ncc.go.jp.ORCID https://orcid.org/0000-0003-4558-9800
Frank SzulzewskyHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Zhiwei QiaoDivision of Rare Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
Mutsumi TakaderaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
Yoshitaka NaritaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, 104-0045, Japan.
Tadashi KondoDivision of Rare Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
Eric C HollandHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA, 98109, USA.
Ryuji HamamotoDivision of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
Koichi IchimuraDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan. kichimur@ncc.go.jp.
National Cancer Research Institute · GBFred Hutch Cancer Center · USNational Cancer Centre Japan · JPNational Cancer Center Hospital East · JPRIKEN Center for Advanced Intelligence Project · JPYokohama City University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent C11orf95-RELA fusions (RELA

Indexed as

Epigenesis, GeneticAnimalsBrain NeoplasmsDNA-Binding ProteinsEpendymomaGene ExpressionGene Expression RegulationGenetic TechniquesHEK293 CellsHumansMiceNF-kappa BOncogene Proteins, FusionProteinsSupratentorial NeoplasmsTranscription Factor RelA2700081o15rik protein, mouseDNA-Binding ProteinsNF-kappa BOncogene Proteins, FusionProteinsRELA protein, humanRela protein, mouseTranscription Factor RelATranscription FactorsZFTA protein, humanEpendymomaFusion geneNF-κB signalingTranscription factor motif

Identifiers

PMID33685520
PMCPMC7941712
OpenAlexW3135517946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.