ReviewAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2021
The pharmacokinetics of epinephrine/adrenaline autoinjectors.
Review in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Effect of scenario-based simulation on students' learning outcomes and satisfaction in perioperative anaphylaxis: a pilot randomised controlled trial.BMJ open quality · 2026Trial
- New Adrenaline Devices for Treating Anaphylaxis: Results of a Joint Survey From the European Anaphylaxis Registry and the Allergy-Vigilance Network.Clinical and translational allergy · 2026Article
- Frequency and Characteristics of Delayed-Onset Inflammatory Nodules After Hyaluronic Acid Injections in Japan.Aesthetic plastic surgery · 2025Article
- Intramuscular epinephrine in cardiac arrest: A systematic review.Resuscitation plus · 2025Review
- Optimizing Adrenaline Administration in Anaphylaxis: Clinical Practice Considerations and Safety Insights.Clinical and translational allergy · 2025Review
- Possession of Injectable Epinephrine Among Children with Parent-Reported Food Allergies in Saudi Arabia.Journal of clinical medicine · 2025Article
- Exploring the anti-anaphylaxis potential of natural products: A Review.Inflammopharmacology · 2025Review
- Alternatives to Injectable Adrenaline for Treating Anaphylaxis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Article
- Identifying patients at risk of anaphylaxis.The World Allergy Organization journal · 2024Review
- Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice.Clinical and translational allergy · 2023Review
- Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia.Therapeutic advances in hematology · 2023Review
- Evidence update for the treatment of anaphylaxis.Resuscitation · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor a century, epinephrine has been the drug of choice for acute treatment of systemic allergic reactions/anaphylaxis. For 40 years, autoinjectors have been used for the treatment of anaphylaxis. Over the last 20 years, intramuscular epinephrine injected into the thigh has been recommended for optimal effect.
objectiveTo review the literature on pharmacokinetics of epinephrine autoinjectors.
resultsSix studies assessing epinephrine autoinjector pharmacokinetics were identified. The studies, all on healthy volunteers, were completed by Simons, Edwards, Duvauchelle, Worm and Turner over the span of 2 decades. Simons et al. published two small studies that suggested that intramuscular injection was superior to subcutaneous injection. These findings were partially supported by Duvauchelle. Duvauchelle showed a proportional increase in C
conclusionsIntramuscular injection with higher doses of epinephrine appears to lead to a higher C
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.