ArticleBMC pediatrics2021
Factors associated with neurodevelopment in preterm infants with systematic inflammation.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The impact of perinatal inflammation on the electroencephalogram in preterm infants: a systematic review.Pediatric research · 2022Pooled it
- Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial.Pediatric research · 2022Trial
- Elevated Serum Neurofilament Light Chain Is Associated With Systemic Inflammation in Very Preterm Infants.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- N-Acetylcysteine protects the developing brain in neonatal sepsis-like inflammation via a redox-neurovascular pathway.Journal of neuroinflammation · 2026Article
- Impact of birth weight on long-term growth and development in children: evidence from a nationwide cohort study.BMC pediatrics · 2026Article
- Systemic inflammatory mediators and neurodevelopmental outcomes in term infants: a retrospective cohort study.BMC pediatrics · 2026Article
- Inflammatory Biomarkers and Neurotrophic Factors in Preterm Newborns as Predictors of Motor Development: A Systematic Review.Pediatric reports · 2026Review
- Neurodevelopmental impairment in infants with necrotizing enterocolitis: a comprehensive review of mechanisms, outcomes, and emerging strategies.World journal of pediatric surgery · 2026Review
- Adverse neurodevelopment after multiple sepsis and/or necrotizing enterocolitis in preterm infants: revisiting single-episode paradigm.Pediatric research · 2026Article
- Serial amplitude-integrated electroencephalography trajectories and brain-injury-associated functional immaturity in extremely preterm infants.Frontiers in pediatrics · 2026Article
- Predicting Neonatal Morbidity and Correlations with Maternal and Neonatal Biomarkers in Connection with Fetal Inflammatory Response Syndrome in Premature Births.Journal of clinical medicine · 2025Article
- Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.The American journal of pathology · 2025Article
- Risk factors and influence on neurodevelopmental outcomes of neonatal seizures in very low birth weight infants based on nationwide cohort.Scientific reports · 2025Article
- Incidence and outcomes of neonatal group B streptococcal sepsis in Qatar-a multicentre study.BMC pediatrics · 2025Article
- Ultrasound combined with serological markers for predicting neonatal necrotizing enterocolitis: a machine learning approach.Frontiers in pediatrics · 2025Article
- Influencing factors and construction of a predictive model for neurodevelopmental outcomes in preterm low birth weight infants.American journal of translational research · 2025Article
- Risk of neurodevelopmental impairment in Swedish preterm children treated for necrotizing enterocolitis: retrospective cohort study.BJS open · 2024Article
- DNA Methylation, Inflammation, and Neurobehavior in Preterm Infants.Biological research for nursing · 2024Article
- Early Postnatal Neuroinflammation Produces Key Features of Diffuse Brain White Matter Injury in Rats.Brain sciences · 2024Article
- [Amplitude-integrated electroencephalography monitoring results of hospitalized neonates in plateau areas].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have suggested that adverse neurodevelopment could be induced by systemic inflammation in preterm infants. We aimed to investigate whether preterm infants with systemic inflammation would have impaired neurodevelopment and which biomarkers and neurophysiologic studies during inflammation are associated with poor neurodevelopment.
methodsThis prospective cohort study enrolled infants born before 30 weeks of gestation or with birth weight < 1250 g. Infants were grouped according to the presence of systemic inflammation: Control (no inflammation, n = 49), I (systemic inflammation, n = 45). Blood and cerebrospinal fluid samples for markers of brain injury and inflammation were collected and amplitude-integrated electroencephalography (aEEG) was performed within 4 h of septic workup. We evaluated aEEG at 35 weeks postmenstrual age (PMA), head circumference at 36 weeks PMA, and brain MRI at discharge. The Bayley Scales of Infant and Toddler Development III (Bayley-III) was performed at a corrected age (CA) of 18 months.
resultsThe I group had more white matter injuries (2 vs. 26.7%, Control vs. I, respectively) at the time of discharge, lower brain functional maturation (9.5 vs. 8), and smaller head size (z-score - 1.45 vs. -2.12) at near-term age and poorer neurodevelopment at a CA of 18 months than the control (p < 0.05). Among the I group, the proportion of immature neutrophils (I/T ratios) and IL-1 beta levels in the CSF were associated with aEEG measures at the day of symptom onset (D0). Seizure spike on aEEG at D0 was significantly correlated with motor and social-emotional domains of Bayley-III (p < 0.05). The I/T ratio and CRP and TNF-α levels of blood at D0, white matter injury on MRI at discharge, head circumference and seizure spikes on aEEG at near-term age were associated with Bayley-III scores at a CA of 18 months.
conclusionsSystemic inflammation induced by clinical infection and NEC are associated with neurodevelopmental impairment in preterm infants. The seizure spike on aEEG, elevated I/T ratio, CRP, and plasma TNF-alpha during inflammatory episodes are associated with poor neurodevelopment.
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