Evidence map›Paper›PMID 33685410›Full record

ArticleBMC cancer2021

Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study.

Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen, Asgeir Store Jakola

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06783842 (Perioperative Depression, an Observational Cohort Study), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06783842 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Perioperative Depression, an Observational Cohort Study

Typeobservational_patient_registrySponsorKarolinska InstitutetRan2025 to 2026Enrolled700,000ConditionsSurgery With General Anesthesia, Depression - Major Depressive Disorder
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Isabelle RydénDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Blå stråket 7, 3 tr, 413 45, Gothenburg, Sweden. isabelle.ryden@neuro.gu.se.ORCID http://orcid.org/0000-0002-2384-9248
Erik ThurinDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Blå stråket 7, 3 tr, 413 45, Gothenburg, Sweden.
Louise CarstamDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Blå stråket 7, 3 tr, 413 45, Gothenburg, Sweden.
Anja SmitsDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Blå stråket 7, 3 tr, 413 45, Gothenburg, Sweden.
Sasha GulatiDepartment of Neurosurgery, St.Olavs University Hospital HF, Trondheim, Norway.
Roger HenrikssonDepartment of Radiation Sciences and Oncology, University of Umea, Umeå, Sweden.
Øyvind SalvesenDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Asgeir Store JakolaDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Blå stråket 7, 3 tr, 413 45, Gothenburg, Sweden.

Funding

Vetenskapsrådet 2017-0944
6 · The paper itself

Abstract

backgroundLow-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patients with LGG, less is known about depression and anxiety.

methodsWe used nationwide registers to study the use (dispense) of antidepressants, sedatives, and anti-epileptic drugs (AEDs) before and after histopathological LGG diagnosis (WHO grade II). A total of 485 adult patients with a first-time diagnosis and a matched control cohort (n = 2412) were included. Patterns of use were analysed from one year prior to until one year following index date (date of surgery). Logistic regression analysis identified predictors for postoperative use.

resultsAt one year before index date, patients were dispensed AEDs 4 times more than controls, while antidepressants and sedatives were similar. Sedatives and AED peaked shortly after index date at 25 and 69%, respectively. AEDs then stabilized while sedatives decreased rapidly. For antidepressants, a delayed increase was seen after index date, stabilizing at 12%. At one year after index date, the use of antidepressants, sedatives, and AEDs among patients was 2, 3, and 26 times higher, respectively, compared to controls. Predictor for use of AEDs and sedatives at one year following index was previous use and/or a related diagnosis. Female sex and later index year were additional predictors for antidepressants.

conclusionsUse of antidepressants, sedatives and AEDs is elevated following diagnosis of LGG. Antidepressants were more commonly dispensed to female patients and in recent years.

Indexed as

AdultAge FactorsAnti-Anxiety AgentsAnticonvulsantsAntidepressive AgentsAnxietyBrain NeoplasmsCase-Control StudiesDepressionDrug PrescriptionsFemaleGliomaHumansMaleMiddle AgedNeoplasm StagingAnti-Anxiety AgentsAnticonvulsantsAntidepressive AgentsAnti-anxiety agentsAnticonvulsantsAntidepressive agentsGlioma; low-grade glioma

Identifiers

PMID33685410
PMCPMC7938599

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.