Evidence map›Paper›PMID 33685366›Full record

ArticleRNA biology2021

Dihydrouridine synthesis in tRNAs is under reductive evolution in Mollicutes.

Bruno Faivre, Murielle Lombard, Soufyan Fakroun, Chau-Duy-Tam Vo, Catherine Goyenvalle, Vincent Guérineau, Ludovic Pecqueur, Marc Fontecave, Valérie De Crécy-Lagard, Damien Brégeon and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  11. Mapping the tRNA modification landscape ofFrontiers in microbiology · 2024
    Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Bruno FaivreLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Murielle LombardLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Soufyan FakrounSorbonne Université, IBPS, Biology of Aging and Adaptation, Paris, France.
Chau-Duy-Tam VoLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Catherine GoyenvalleSorbonne Université, IBPS, Biology of Aging and Adaptation, Paris, France.
Vincent GuérineauInstitue De Chimie De Substances Naturelles, Centre De Recherche De Gif CNRS, Gif-sur-Yvette, France.
Ludovic PecqueurLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Marc FontecaveLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Valérie De Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA; University of Florida Genetics Institute, Gainesville, FL, USA.
Damien BrégeonSorbonne Université, IBPS, Biology of Aging and Adaptation, Paris, France.
Djemel HamdaneLaboratoire De Chimie Des Processus Biologiques, CNRS-UMR 8229, Collège De France, Sorbonne Université, UPMC Université. Paris 06, Paris, France.
Centre National de la Recherche Scientifique · FRSorbonne Université · FRUniversity of Florida · US

Funding

Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3M
NIGMS NIH HHS R01 GM070641
6 · The paper itself

Abstract

Dihydrouridine (D) is a tRNA-modified base conserved throughout all kingdoms of life and assuming an important structural role. The conserved dihydrouridine synthases (Dus) carries out D-synthesis. DusA, DusB and DusC are bacterial members, and their substrate specificity has been determined in

Indexed as

Bacterial ProteinsCloning, MolecularEscherichia coliEvolution, MolecularModels, MolecularNucleic Acid ConformationOxidoreductasesRNA, BacterialRNA, TransferSubstrate SpecificityTenericutesUridineBacterial ProteinsOxidoreductasesRNA, BacterialRNA, TransfertRNA-dihydrouridine synthaseUridinedihydrouridinemollicutesmultisite-specificitypost-transcriptional modificationtRNA

Identifiers

PMID33685366
PMCPMC8632129
OpenAlexW3134966064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.