Evidence map›Paper›PMID 33684722›Full record

ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2021

Rapid quantification of vincristine in mouse plasma using ESI-LC-MS/MS: Application to pharmacokinetic studies.

Yan Jin, Yang Li, Muhammad Erfan Uddin, Alex Sparreboom, Shuiying Hu

Open access · greenAbstract read
In one paragraph

Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.Drug metabolism and disposition: the biological fate of chemicals · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yan JinDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Yang LiDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Muhammad Erfan UddinDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Alex SparreboomDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Shuiying HuDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA. Electronic address: hu.1333@osu.edu.
The Ohio State University · US

Funding

Prevention of paclitaxel-induced peripheral neuropathy with nilotinibR01CA238946 · NCI · OHIO STATE UNIVERSITY · PI HU, SHUIYING, LUSTBERG, MARYAM B. · 2019 to 2023
$2.9M
(9) Therapeutic strategies to mitigate toxicities of platinum-based therapeuticsR01CA215802 · NCI · OHIO STATE UNIVERSITY · PI PABLA, NAVJOT, SPARREBOOM, ALEXANDER · 2017 to 2021
$2.5M
Organic cation transporter 2 and cisplatin nephrotoxicityR01CA151633 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SPARREBOOM, ALEXANDER · 2010 to 2014
$2.0M
NCI NIH HHS R01 CA151633NCI NIH HHS R01 CA215802NCI NIH HHS R01 CA238946
6 · The paper itself

Abstract

A simple, rapid, and sensitive LC-MS/MS method for determining concentrations of the anticancer alkaloid vincristine in micro volumes of mouse plasma was developed and validated in positive ion mode. Separation of vincristine and the internal standard [

Indexed as

AnimalsChromatography, High Pressure LiquidLimit of DetectionLinear ModelsMaleMiceReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryVincristineVincristineMouse plasmaPharmacokineticsUHPLC-MS/MSVincristine

Identifiers

PMID33684722
PMCPMC7987214
OpenAlexW3132776754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.