ArticleProceedings of the National Academy of Sciences of the United States of America1988
Cloning and characterization of a potentially protective antigen in lymphatic filariasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.The Journal of antibiotics · 2015Article
- Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.The Journal of antibiotics · 2014Article
- Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.Organic letters · 2011Article
- Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.Journal of computer-aided molecular design · 2006Article
- Asn-tRNA in Lactobacillus bulgaricus is formed by asparaginylation of tRNA and not by transamidation of Asp-tRNA.Nucleic acids research · 1996Article
- Serodiagnosis of parasitic diseases.Clinical microbiology reviews · 1991Review
- Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.Nucleic acids research · 1991Article
- Molecular parasitology: progress towards the development of vaccines for malaria, filariasis, and schistosomiasis.Experientia · 1991Review
- Protective immune responses with trickle infections of third-stage filarial larvae of Wuchereria bancrofti in mice.Clinical and experimental immunology · 1989Article
- Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi.Nucleic acids research · 1989Article
- Clinical and laboratory aspects of filariasis.Clinical microbiology reviews · 1989Review
- A 22-nucleotide spliced leader sequence in the human parasitic nematode Brugia malayi is identical to the trans-spliced leader exon in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
To facilitate biochemical studies of protective filarial antigens, a lambda gt11 cDNA library was constructed from Brugia malayi adult mRNA and screened with rabbit sera that recognizes a limited set of filarial antigens of approximately 25, 42, 60, and 112 kDa. Antigens of approximately equal to 25 and approximately equal to 60 kDa have been shown previously to induce enhanced clearance of microfilaremia in mice. A 154-base pair clone detected by immunological reactivity was used to isolate by hybridization a nearly full-length cDNA clone of 1.8 kilobases. Nucleotide-sequence analysis indicated that this clone was derived from a mRNA encoding a 63-kDa antigen. A fusion polypeptide containing 37 kDa of the Escherichia coli TrpE protein (anthranilate synthase) and 55 kDa of the cloned protein was recognized in immunoblot experiments with antisera raised against a partially purified preparation of the approximately equal to 60-kDa protective filarial antigen. These data relate the cloned antigen to a potentially protective antigen in lymphatic filariasis.
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