ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Prefrontal lesions disrupt oscillatory signatures of spatiotemporal integration in working memory.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Neural mechanisms of feature binding in working memory.Communications biology · 2026Article
- The development of aperiodic neural activity in the human brain.Nature human behaviour · 2025Article
- Spatial memory deficits in Parkinson's disease: neural mechanisms and assessment.American journal of neurodegenerative disease · 2025Review
- Distinct neural patterns for various information in working memory: A brain connectivity study.PloS one · 2025Article
- Cortical and white matter substrates supporting visuospatial working memory.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory.Neuroscience bulletin · 2024Article
- Effective connectivity of working memory performance: a DCM study of MEG data.Frontiers in human neuroscience · 2024Article
- Inter-individual variability during neurodevelopment: an investigation of linear and nonlinear resting-state EEG features in an age-homogenous group of infants.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A rapid theta network mechanism for flexible information encoding.Nature communications · 2023Article
- Causal link between prefrontal cortex and EEG microstates: evidence from patients with prefrontal lesion.Frontiers in neuroscience · 2023Article
- Fronto-medial theta coordinates posterior maintenance of working memory content.Current biology : CB · 2022Article
- Individual predictors and electrophysiological signatures of working memory enhancement in aging.NeuroImage · 2022Article
- Prefrontal Lesions Disrupt Posterior Alpha-Gamma Coordination of Visual Working Memory Representations.Journal of cognitive neuroscience · 2021Article
- Use of Fast Gamma Magnetic Stimulation Over the Left Prefrontal Dorsolateral Cortex for the Treatment of MCI and Mild Alzheimer's Disease: A Double-Blind, Randomized, Sham-Controlled, Pilot Study.Frontiers in neurology · 2021Article
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5 authors.
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Abstract
How does the human brain integrate spatial and temporal information into unified mnemonic representations? Building on classic theories of feature binding, we first define the oscillatory signatures of integrating 'where' and 'when' information in working memory (WM) and then investigate the role of prefrontal cortex (PFC) in spatiotemporal integration. Fourteen individuals with lateral PFC damage and 20 healthy controls completed a visuospatial WM task while electroencephalography (EEG) was recorded. On each trial, two shapes were presented sequentially in a top/bottom spatial orientation. We defined EEG signatures of spatiotemporal integration by comparing the maintenance of two possible where-when configurations: the first shape presented on top and the reverse. Frontal delta-theta (δθ; 2-7 Hz) activity, frontal-posterior δθ functional connectivity, lateral posterior event-related potentials, and mesial posterior alpha phase-to-gamma amplitude coupling dissociated the two configurations in controls. WM performance and frontal and mesial posterior signatures of spatiotemporal integration were diminished in PFC lesion patients, whereas lateral posterior signatures were intact. These findings reveal both PFC-dependent and independent substrates of spatiotemporal integration and link optimal performance to PFC.
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