Evidence map›Paper›PMID 33684605›Full record

ArticleSleep medicine2021

Wake-up stroke is not associated with obstructive sleep apnea.

Sonja G Schütz, Lynda D Lisabeth, River Gibbs, Xu Shi, Erin Case, Ronald D Chervin, Devin L Brown

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sonja G SchützSleep Disorders Center, Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: schuetzs@umich.edu.
Lynda D LisabethDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA; Stroke Program - Cardiovascular Center, Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: llisabet@umich.edu.
River GibbsDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA. Electronic address: rivgibbs@umich.edu.
Xu ShiDepartment of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA. Electronic address: shixu@umich.edu.
Erin CaseDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA. Electronic address: erincase@med.umich.edu.
Ronald D ChervinSleep Disorders Center, Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: chervin@med.umich.edu.
Devin L BrownStroke Program - Cardiovascular Center, Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: devinb@umich.edu.
University of Michigan · US

Funding

STROKE SURVEILLANCE IN A BIETHNIC COMMUNITYR01NS038916 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LISABETH, LYNDA D, MORGENSTERN, LEWIS B · 1999 to 2023
$20.9M
Sleep apnea after stroke: Implications for screening and treatmentR01HL126700 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2016 to 2019
$3.0M
Sleep apnea health disparities in Mexican American stroke patientsR01NS070941 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2011 to 2015
$2.6M
The epidemiology of sleep apnea in a bi-ethnic stroke populationR01HL098065 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL098065NHLBI NIH HHS R01 HL126700NINDS NIH HHS R01 NS038916NINDS NIH HHS R01 NS070941
6 · The paper itself

Abstract

OBJECTIVE/

backgroundObstructive sleep apnea is a risk factor for stroke. This study sought to assess the relationship between obstructive sleep apnea (OSA) and wake-up strokes (WUS), that is, stroke symptoms that are first noted upon awakening from sleep. PATIENTS/

methodsIn this analysis, 837 Brain Attack Surveillance in Corpus Christi (BASIC) project participants completed an interview to ascertain stroke onset during sleep (WUS) versus wakefulness (non-wake-up stroke, non-WUS). A subset of 316 participants underwent a home sleep apnea test (HSAT) shortly after ischemic stroke to assess for OSA. Regression models were used to test the association between OSA and WUS, stratified by sex.

resultsOf 837 participants who completed the interview, 251 (30%) reported WUS. Among participants who underwent an HSAT, there was no significant difference in OSA severity [respiratory event index (REI)] among participants with WUS [median REI 17, interquartile range (IQR) 10, 29] versus non-WUS (median REI 18, IQR 9, 30; p = 0.73). OSA severity was not associated with increased odds of WUS among men [unadjusted odds ratio (OR) 1.011, 95% confidence interval (95% CI) 0.995, 1.027] or women (unadjusted OR 0.987, 95% CI 0.959, 1.015). These results remained unchanged after adjustment for age, congestive heart failure, body mass index, and pre-stroke depression in men (adjusted OR 1.011, 95% CI 0.994, 1.028) and women (adjusted OR 0.988, 95% CI 0.959, 1.018).

conclusionsAlthough OSA is a risk factor for stroke, the onset of stroke during sleep is not associated with OSA in this large, population-based stroke cohort.

Indexed as

Brain IschemiaIschemic StrokeSleep Apnea, ObstructiveStrokeFemaleHumansMalePolysomnographyRisk FactorsHome sleep apnea testIschemic strokeObstructive sleep apneaSleep-disordered breathingWake-up stroke

Identifiers

PMID33684605
PMCPMC8563108
OpenAlexW3128646080

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.