ArticleProceedings of the National Academy of Sciences of the United States of America1988
The 28-kDa calbindin-D is a major calcium-binding protein in the basilar papilla of the chick.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 74 citations in OpenAlex.
- Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration.Frontiers in cell and developmental biology · 2026Review
- A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles.Biophysical journal · 2017Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- Correlation of actin crosslinker and capper expression levels with stereocilia growth phases.Molecular & cellular proteomics : MCP · 2014Article
- Electrical tuning and transduction in short hair cells of the chicken auditory papilla.Journal of neurophysiology · 2013Article
- Distinct energy metabolism of auditory and vestibular sensory epithelia revealed by quantitative mass spectrometry using MS2 intensity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Expression of calcium binding proteins in mouse type II taste cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry.Biochemistry · 2009Article
- The distribution of calcium buffering proteins in the turtle cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Topological and developmental gradients of calbindin expression in the chick's inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2002Article
- Contribution of the plasmalemma to Ca2+ homeostasis in hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Development and dissipation of Ca(2+) gradients in adrenal chromaffin cells.Biophysical journal · 2000Article
- The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Molecular markers for cell types of the inner ear and candidate genes for hearing disorders.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Sensory cells determine afferent terminal morphology in cross-innervated electroreceptor organs: implications for hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Intrinsic controls of intracellular calcium and intercellular communication in the regulation of neuroendocrine cell activity.Cellular and molecular neurobiology · 1998Review
- A theoretical study of calcium microdomains in turtle hair cells.Biophysical journal · 1996Article
- Monitoring calcium in turtle hair cells with a calcium-activated potassium channel.The Journal of physiology · 1996Article
- A developmental model for generating frequency maps in the reptilian and avian cochleas.Biophysical journal · 1996Article
- The calcium-activated potassium channels of turtle hair cells.The Journal of general physiology · 1995Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
In previous work we identified a basilar papilla protein (BPP23) that appears to be one of the most abundant soluble proteins in the basilar papilla of the chick cochlea. Here we report the purification of protein BPP23 from chick cochlea and the generation of a specific antiserum. Immunoblotting and immunoprecipitation experiments with this antiserum indicate that BPP23 is a calcium-binding protein very similar, if not identical, to avian calbindin, the 28-kDa vitamin D-dependent calcium-binding protein. Although the basilar papilla contains both receptor hair cells and supporting cells, immunocytochemical studies by others have localized calbindin-like immunoreactivity to the hair cells in the rat auditory receptor epithelium. Our estimates of the abundance of protein BPP23, assuming exclusive localization within the hair cell, indicate a concentration of at least 1 mM. Avian calbindin has four high-affinity (Kd = 0.5 X 10(-6)) calcium-binding sites. The presence of a specific calcium-binding activity at such high levels suggests an important function for cochlear calbindin (BPP23) in hair cell calcium homeostasis and auditory transduction.
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