Evidence map›Paper›PMID 33684366›Full record

ArticleArchives of physical medicine and rehabilitation2021

Trunk Muscle Characteristics: Differences Between Sedentary Adults With and Without Unilateral Lower Limb Amputation.

Jaclyn M Sions, Emma H Beisheim, Mark A Hoggarth, James M Elliott, Gregory E Hicks, Ryan T Pohlig, Mayank Seth

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. [Hemodynamic study of muscle perfusion in amputees].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  7. Observational
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jaclyn M SionsDepartment of Physical Therapy, Delaware Limb Loss Studies, University of Delaware, Newark, DE. Electronic address: megsions@udel.edu.
Emma H BeisheimDepartment of Physical Therapy, Delaware Limb Loss Studies, University of Delaware, Newark, DE.
Mark A HoggarthDepartment of Biomedical Engineering, Northwestern University, Evanston, IL.
James M ElliottUniversity of Sydney, The Kolling Research Institution, Faculty of Medicine and Health, and The Northern Sydney Local Health District, Sydney, Australia; Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Gregory E HicksDepartment of Physical Therapy, Delaware Spine Studies, University of Delaware, Newark, DE.
Ryan T PohligUniversity of Delaware, Biostatistics Core Facility, Newark, DE.
Mayank SethDepartment of Physical Therapy, Delaware Limb Loss Studies, University of Delaware, Newark, DE.
University of Delaware · USNorthern Sydney Local Health District · AUNorthwestern University · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
Trunk Muscle Characteristics and their Association with Balance, Function, and Participation among Individuals with AmputationsR03HD088668 · NICHD · UNIVERSITY OF DELAWARE · PI SIONS, JACLYN MEGAN · 2017 to 2018
$156k
NICHD NIH HHS R03 HD088668NICHD NIH HHS T32 HD007490NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

objectiveThe primary purpose of this study was to compare trunk muscle characteristics between adults with and without unilateral lower limb amputation (LLA) to determine the presence of modifiable trunk muscle deficits (ie, impaired activity, reduced volume, increased intramuscular fat) evaluated by ultrasonography (US) and magnetic resonance imaging (MRI). We hypothesized that compared with adults without LLA (controls), individuals with transfemoral or transtibial LLA would demonstrate reduced multifidi activity, worse multifidi and erector spinae morphology, and greater side-to-side trunk muscle asymmetries.

designCross-sectional imaging study.

settingResearch laboratory and imaging center.

participantsSedentary adults (n=38 total) with LLA (n=9 transfemoral level; n=14 transtibial level) and controls without LLA (n=15).

interventionsNot applicable.

main outcome measuresWe examined bilateral multifidi activity using US at levels L3/L4-L5/S1. MRI was performed using 3-dimensional quantitative fat-water imaging; bilateral L1-L5 multifidi and erector spinae were manually traced, and muscle volume (normalized to body weight) and percentage intramuscular fat were determined. Between-group and side-to-side differences were evaluated.

resultsCompared with adults without LLA, participants with LLA demonstrated reduced sound-side multifidi activity; those with transfemoral LLA had larger amputated-side multifidi volume, whereas those with transtibial LLA had greater sound- and amputated-side erector spinae intramuscular fat (P<.050). With transfemoral LLA, side-to-side differences in erector spinae volume, as well as multifidi and erector spinae intramuscular fat, were found (P<.050).

conclusionsImpaired trunk muscle activity and increased intramuscular fat may be modifiable targets for intervention after LLA.

Indexed as

AmputeesSedentary BehaviorAdultBack MusclesCross-Sectional StudiesFemaleHumansLower ExtremityMagnetic Resonance ImagingMaleMiddle AgedTorsoUltrasonographyAmputationArtificial limbsAtrophyBackDisuseMagnetic resonance imagingParaspinal musclesRehabilitationReliabilityUltrasonography

Identifiers

PMID33684366
PMCPMC8263498
OpenAlexW3134670608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.