ArticleAngewandte Chemie (International ed. in English)2021
Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS).
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Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- The Regulatory Landscape of Ferroptosis and Iron Homeostasis: Pathophysiological Mechanisms and Therapeutic Horizons in Cardiovascular Disease.Drug design, development and therapy · 2026Review
- Ferroptosis: key regulatory pathways and their implications in cardiovascular pathophysiology.Frontiers in cardiovascular medicine · 2026Review
- Emerging Roles of Ferroptosis in Skin Pathophysiology.The Journal of investigative dermatology · 2025Review
- 15-Lipoxygenase-dependent radiomitigation by NORedox biology · 2025Article
- Multimodal Ion Beam Imaging to Correlate Elements and Metabolites at the Micron Scale Using Water Cluster Secondary Ion Mass Spectrometry and MeV Ion Beam Analysis.Analytical chemistry · 2025Article
- Single-cell mass spectrometry imaging of lipids in HeLa cells via tapping-mode scanning probe electrospray ionization.Communications chemistry · 2025Article
- PPAR γ changing ALDH1A3 content to regulate lipid metabolism and inhibit lung cancer cell growth.Molecular genetics and genomics : MGG · 2025Article
- Research progress on the cross-regulation between ferroptosis and immunogenic cell death in tumor micro-environment.Frontiers in oncology · 2025Review
- Autosis: a new form of cell death in myocardial ischemia-reperfusion injury.Molecular and cellular biochemistry · 2025Review
- Mass spectrometry imaging for unearthing and validating quality markers in traditional Chinese medicines.Chinese herbal medicines · 2025Review
- PCA, PC-CVA, and Random Forest of GCIB-SIMS Data for the Elucidation of Bacterial Envelope Differences in Antibiotic Resistance Research.Analytical chemistry · 2024Article
- Ferroptosis in health and disease.Redox biology · 2024Review
- Frontiers in Mass Spectrometry-Based Spatial Metabolomics: Current Applications and Challenges in the Context of Biomedical Research.Trends in analytical chemistry : TRAC · 2024Article
- Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation.EBioMedicine · 2024Review
- Advances in multimodal mass spectrometry for single-cell analysis and imaging enhancement.FEBS letters · 2024Review
- Ferroptosis at the nexus of metabolism and metabolic diseases.Theranostics · 2024Review
- Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.Advances in cancer research · 2024Review
- Review
- Molecular therapy of cardiac ischemia-reperfusion injury based on mitochondria and ferroptosis.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains.Redox biology · 2023Article
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Authors and funding
13 authors at 4 institutions in 3 countries.
Louis J SparveroDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID 0000-0001-6347-8448
Hua TianDepartment of Chemistry, Pennsylvania State University, University Park, State College, PA, 16802, USA.
Andrew A AmoscatoDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Wan-Yang SunCollege of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632, China.
Tamil S AnthonymuthuDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Yulia Y TyurinaDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Oleksandr KapralovDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Sabzali JavadovDepartment of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, 00936-5067, USA.
Rong-Rong HeCollege of Pharmacy and School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Simon C WatkinsDepartment of Cell Biology and Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Nicholas WinogradDepartment of Chemistry, Pennsylvania State University, University Park, State College, PA, 16802, USA.
Valerian E KaganDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Hülya BayırDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
University of Pittsburgh · USJinan University · CNPennsylvania State University · USUniversity of Puerto Rico System · PR
Funding
Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4MRegulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3MMapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8MFluorescent Biosensors for Networks and PathwaysU54GM103529 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI WAGGONER, ALAN S. · 2012 to 2013
$6.3MLipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8MOxidative Lipidomics in Pediatric Traumatic Brain InjuryR01NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2008 to 2018
$3.3MProtein-Oxidized Phospholipid Interactions Determine Epithelial Cell Fate and Asthma Control R01AI145406 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sally E Wenzel · 2020 to 2026
$2.9MDruggable Mitochondrial Targets for Treatment of Cerebral IschemiaR01NS117000 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA, CLARK, ROBERT S B · 2020 to 2024
$2.9MRegulation of tumor recurrence by stress activated neutrophilsR01CA243142 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2020 to 2025
$2.8MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MRadiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos PyroptosisU01AI156923 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2020 to 2024
$2.4MSelective Inhibitors of Pro-Ferroptotic Lipoxygenases - Next Generation RadiomitigatorsU01AI156924 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2020 to 2024
$2.3MNCI NIH HHS R01 CA165065NCI NIH HHS R01 CA243142NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL151078NIAID NIH HHS R01 AI145406NIAID NIH HHS U01 AI156923NIAID NIH HHS U01 AI156924NIAID NIH HHS U19 AI068021NIGMS NIH HHS R01 GM113908NIGMS NIH HHS R01 GM134715NIGMS NIH HHS U54 GM103529NINDS NIH HHS R01 NS061817NINDS NIH HHS R01 NS076511NINDS NIH HHS R01 NS117000NINDS NIH HHS R37 NS061817
Abstract
Peroxidized phosphatidylethanolamine (PEox) species have been identified by liquid chromatography mass spectrometry (LC-MS) as predictive biomarkers of ferroptosis, a new program of regulated cell death. However, the presence and subcellular distribution of PEox in specific cell types and tissues have not been directly detected by imaging protocols. By applying gas cluster ion beam secondary ion mass spectrometry (GCIB-SIMS) imaging with a 70 keV (H
Indexed as
AnimalsBrainBrain Injuries, TraumaticCarbolinesCell LineFerroptosisLipid PeroxidationMaleNeuronsPhosphatidylethanolaminesRatsRats, Sprague-DawleySpectrometry, Mass, Secondary IonCarbolinesPhosphatidylethanolaminesRSL3 compoundcell deathimaginglipidmass spectrometryoxidation
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