Evaluating Input Domain and Model Selection for Deep Network Ultrasound Beamforming.

Improving ultrasound B-mode image quality remains an important area of research. Recently, there has been increased interest in using deep neural networks (DNNs) to perform beamforming to improve image quality more efficiently. Several approaches have been proposed that use different representations of channel data for network processing, including a frequency-domain approach that we previously developed. We previously assumed that the frequency domain would be more robust to varying pulse shapes. However, frequency- and time-domain implementations have not been directly compared. In addition, because our approach operates on aperture domain data as an intermediate beamforming step, a discrepancy often exists between network performance and image quality on fully reconstructed images, making model selection challenging. Here, we perform a systematic comparison of frequency- and time-domain implementations. In addition, we propose a contrast-to-noise ratio (CNR)-based regularization to address previous challenges with model selection. Training channel data were generated from simulated anechoic cysts. Test channel data were generated from simulated anechoic cysts with and without varied pulse shapes, in addition to physical phantom and in vivo data. We demonstrate that simplified time-domain implementations are more robust than we previously assumed, especially when using phase preserving data representations. Specifically, 0.39- and 0.36-dB median improvements in in vivo CNR compared to DAS were achieved with frequency- and time-domain implementations, respectively. We also demonstrate that CNR regularization improves the correlation between training validation loss and simulated CNR by 0.83 and between simulated and in vivo CNR by 0.35 compared to DNNs trained without CNR regularization.