Evidence map›Paper›PMID 33683890›Full record

ArticleThe journal of physical chemistry. B2021

Structural Arrangement within a Peptide Fibril Derived from the Glaucoma-Associated Myocilin Olfactomedin Domain.

Yuan Gao, Emily G Saccuzzo, Shannon E Hill, Dustin J E Huard, Alicia S Robang, Raquel L Lieberman, Anant K Paravastu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Myocilin misfolding and glaucoma: A 20-year update.Progress in retinal and eye research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuan Gao
Emily G Saccuzzo
Shannon E Hill
Dustin J E Huard
Alicia S Robang
Raquel L LiebermanORCID 0000-0001-9345-3735
Anant K ParavastuORCID 0000-0001-7183-1942

Funding

Request for Supplement to Promote Diversity in Health Related ResearchR01EY021205 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Raquel L Lieberman · 2011 to 2026
$6.8M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
Solid State NMR Structural Analysis of Oligomeric Alzheimer's Beta-Amyloid PeptideR01AG045703 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PARAVASTU, ANANT KRISHNA · 2014 to 2018
$1.5M
NEI NIH HHS R01 EY021205NEI NIH HHS T32 EY007092NIA NIH HHS R01 AG045703
6 · The paper itself

Abstract

Myocilin-associated glaucoma is a new addition to the list of diseases linked to protein misfolding and amyloid formation. Single point variants of the ∼257-residue myocilin olfactomedin domain (mOLF) lead to mutant myocilin aggregation. Here, we analyze the 12-residue peptide P1 (GAVVYSGSLYFQ), corresponding to residues 326-337 of mOLF, previously shown to form amyloid fibrils

Indexed as

GlaucomaGlycoproteinsAmyloidAmyloid beta-PeptidesCytoskeletal ProteinsExtracellular Matrix ProteinsEye ProteinsHumansMyocilinAmyloidAmyloid beta-PeptidesCytoskeletal ProteinsExtracellular Matrix ProteinsEye ProteinsGlycoproteinsMyocilinolfactomedin

Identifiers

PMID33683890
PMCPMC8771281

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.