Evidence map›Paper›PMID 33683872›Full record

ArticleACS applied materials & interfaces2021

Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment.

Shichao Zhang, Justin Vaida, Josh Parenti, Brock A Lindsey, Malcolm Xing, Bingyun Li

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Shichao ZhangDepartment of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID http://orcid.org/0000-0003-2778-1751
Justin VaidaDepartment of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Josh ParentiDepartment of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Brock A LindseyDepartment of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.
Malcolm XingDepartment of Mechanical Engineering, University of Manitoba, and the Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada.ORCID http://orcid.org/0000-0002-3547-0462
Bingyun LiDepartment of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID http://orcid.org/0000-0002-5766-5666
West Virginia University · USChildren's Hospital Research Institute of Manitoba · CA

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
WVU &MU NEW FACULTY GRANTSP20RR016477 · NCRR · MARSHALL UNIVERSITY · PI RANKIN, GARY O · 2001 to 2011
$35.5M
West Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY · 2014 to 2024
$24.5M
West Virginia Flow Cytometry Core FacilityP30GM103488 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2012 to 2016
$4.8M
NCRR NIH HHS P20 RR016477NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM109098NIGMS NIH HHS P30 GM103488NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (

Indexed as

AnimalsAnti-Bacterial AgentsBacterial InfectionsBiomimetic MaterialsBone and BonesBone Morphogenetic Protein 2Cell LineCirsiumDelayed-Action PreparationsHumansInterleukin-12NanocapsulesPeptidesRatsAnti-Bacterial AgentsBone Morphogenetic Protein 2Delayed-Action PreparationsInterleukin-12NanocapsulesPeptidesanti-infectionbone regenerationdrug deliveryfractureimplant nanocoatingself-assemblytrauma

Identifiers

PMID33683872
PMCPMC10401608
OpenAlexW3134783462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.